Effect of changing levels of glucocorticosteroids on body temperature on exposure to cold

Chowers, I.; Conforti, N.; Feldman, Sanford E.

doi:10.1152/ajplegacy.1970.218.6.1563

Cited by 7 publications

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“…We found that serum corticosterone levels were increased under acute cold stress. This observation is consistent with others 50,51) . Several studies have shown that GC regulate the differentiation of the cells of monocyte/macrophage lineage [52][53][54] .…”

Section: Introductionsupporting

confidence: 94%

Stress- and Aging-Associated Modulation of Macrophage Functions.

Kizaki

Suzuki

Ookawara

et al. 2002

Environ. Health Prev. Med.

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Effects of environmental (cold) stress and aging on cells in monocyte/macrophage lineage were investigated. We demonstrated that immune suppressive states seen in acute cold-stressed mice (8-10 weeks of age) is attributable to Fc1RII bright suppressor macrophages. Serum corticosterone levels were markedly increased in acute cold-stressed mice. In addition, expression of glucocorticoids (GC) receptor mRNA was observed in Fc1RII bright cells from these mice. The increase of Fc1RII bright cells in peritoneal exudate cells caused by acute cold stress was inhibited by adrenalectomy or administration of a saturating amount of the GC antagonist RU 38486 (mifepristone). On the contrary, administration of the GC agonist, dexamethasone, markedly increased the proportion of Fc1RII bright cells in peritoneal exudate cells of control mice. These results suggest that the generation of Fc1RII bright suppressor cells of monocyte/macrophage lineage by acute cold stress was mediated by action of GC through the GC receptor. We likewise found that the proportion of Fc1RII bright suppressor macrophages is increased in aged mice (22-24 months of age). Meanwhile, activated macrophages which function as antigen presenting cells were decreased in aged rats. Both the basal corticosterone concentrations in serum and the expression of mRNA for GC receptor in peritoneal macrophages increased significantly in aged animals, suggesting that these populational and functional changes of macrophages in aged animals were mediated, in part, by the increased basal levels of GC. This is probably being responsible for immunosenescence.

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Section: Introductionsupporting

confidence: 94%

Stress- and Aging-Associated Modulation of Macrophage Functions.

Kizaki

Suzuki

Ookawara

et al. 2002

Environ. Health Prev. Med.

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“…Exogenously increased or decreased GCS levels result in an inefficient response of the temperature-regulation effector or affector system responsible for maintaining optimal BT (CHOWERS et al, 1970). In contrast to acute cold exposure, on acute exposure to heat the increase in the secretion of GCS or mineralocorticosteroids is not sufficient to cope with the stress imposed on the animal.…”

Section: Resultsmentioning

confidence: 99%

Effects of Changing Levels of Glucocorticosteroids on Heat Exposure in Rabbit

1975

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Interaction effects of d-amphetamine treatment and ambient temperature on rat's food intake

Yehuda

1976

Psychopharmacologia

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The "thermoregulatory theory of hunger" posits that rats placed in a cold environment should increase the amount of food intake, while rats placed in a hot environment should decrease their food intake. d-Amphetamine causes hyperthermia among rats kept at warm ambient temperature, and results in hypothermia among animals kept in a cold environment. d-Amphetamine-caused-hyperthermia should therefore result in decreased eating behavior, and d-amphetamine-caused hypothermia should result in increased eating behavior. One must take into account the fact that d-amphetamine is an anorexic drug. The interaction between (a) ambient temperature, (b) body temperature and (c) food intake were tested on groups of rats injected with various doses of d-amphetamine (1.5-15 mg/kg) and placed in ambient temperatures ranging from 4-37 degrees C. No increase in food intake was revealed under any dosage or temperature condition. The decrease in food intake found with d-amphetamine treated animals could not be explained in the "thermoregulatory theory of hunger". Our data indicate that d-amphetamine anorexic effects and thermal effects are mediated by different mechanisms.

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Effect of changing levels of glucocorticosteroids on body temperature on exposure to cold

Cited by 7 publications

References 0 publications

Stress- and Aging-Associated Modulation of Macrophage Functions.

Stress- and Aging-Associated Modulation of Macrophage Functions.

Effects of Changing Levels of Glucocorticosteroids on Heat Exposure in Rabbit

Interaction effects of d-amphetamine treatment and ambient temperature on rat's food intake

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