The present study considers MHD Casson nanofluid flow and explore the intriguing effects of suction and injection over a nonlinearly stretched surface through porous media. The Joule heating effect is considered which is the physical process that transforms electrical energy to thermal energy. Nanofluids with definite thermal radiation features can be useful in medical treatments, and energy storage systems, and also can be used as coatings to provide thermal insulation. Nanofluids with chemical reactions have various applications such as the removal of pollutants from water, biomedical field, and catalysts in industrial processes. The chemical reaction is also taken into consideration in this study. The Keller box method is employed to solve the governing equations. Various parameters effects are analysed using graphical representations of concentration, velocity, and temperature. Observing augmented values of porosity, suction/injection, and stretching parameters reveals a decrease in velocity profiles. On the other hand, progressive observations of porosity, Casson, radiation, and Joule heating parameters result in enhanced temperature profiles. Conversely, a reverse trend is observed in the case of nonlinearity and suction/injection constraints. The concentration profile decreases for enhanced observations of heat source parameters. Nusselt number, skin friction, and Sherwood numbers are also calculated. It is witnessed that the skin friction coefficient rises with a higher estimation of the porosity parameter. Nusselt number increases in case of the chemical reaction and nonlinear stretching parameter. Sherwood number decreases for progressive values of chemical reaction and thermophoresis parameters.