Effect of chemogenetic modulation of hippocampal neurons on depression and spatial memory impairment in a rat model for temporal lobe epilepsy.

Chemogenetics: Beyond Lesions and Electrodes

“…Seizures have been sustainably suppressed by activating DREADDs in different animal models (ie, acute chemoconvulsant rodent model, chronic epilepsy rodent model, mouse intrahippocampal model, and mouse intraperitoneal pilocarpine model). [87][88][89][90] From a clinical standpoint, mesial temporal lobe sclerosis, gray matter heterotopia, and other lesional epilepsy types often warrant destructive and ablative procedures. [91][92][93][94][95] Even though epilepsy surgery is associated with acceptable seizure free survival rates, the authors believe that chemogenetics could provide a superior safety and efficacy profile in the management of drug-resistant epilepsy.…”