Effect of Chemoprophlaxis on the Meningococcal State After Systemic Infection

Effectiveness of antibiotics in preventing meningococcal disease after a case: systematic review

“…Four studies assessed persistent meningogcoccal carriage on discharge from hospital in patients who had not received chemoprophylaxis. Alvez et al showed that three of 48 children (aged 3 months to 13 years) who were treated with 300 000 units/kg/day of penicillin G sodium intravenously for at least 10 days were carriers of Neisseria meningitidis on discharge 17. In the study of Abramson and Spika meningococci were cultured from the upper respiratory tract in one of 14 patients discharged after completion of intravenous therapy, initially with ampicillin or chloramphenicol then benzyl penicillin 18.…”

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

“…However, detailed studies found pathogenic meningococci in only a very small percentage (ca. 1%) of patients after discharge, and therefore the efficacy of sterilizing the naso-oropharynx before discharge is controversial (7,528).…”