Effect of chemoradiation on the size of the thyroid gland

Rivas, Ana Marcella; Larumbe-Zabala, Eneko; Díaz-Trastoy, Olaia; Schurr, Ryan; Jones, Catherine; Abdulrahman, Ramzi; Dar, Nabeel; Lado-Abeal, Joaquín

doi:10.1080/08998280.2020.1786227

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…This complication may be associated with radiation-induced thyroid volume reduction. Recent studies, mostly relatively small, have reported a significant decrease in thyroid volume (14–30 %) in patients with laryngeal cancer or nasopharyngeal carcinoma (NPC), suggesting an association between the development of HT and post-RT thyroid atrophy [10] , [11] . In breast cancer patients, smaller thyroid volume has been associated with a higher incidence of radiation-induced HT [12] .…”

Section: Introductionmentioning

confidence: 99%

Thyroid volume changes following adjuvant radiation therapy for breast cancer

Roberson

Huang

Noldner

et al. 2023

Clinical and Translational Radiation Oncology

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Section: Introductionmentioning

confidence: 99%

Thyroid volume changes following adjuvant radiation therapy for breast cancer

Roberson

Huang

Noldner

et al. 2023

Clinical and Translational Radiation Oncology

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“…Specifically, irradiation to the supraclavicular field was associated with an increased risk of hypothyroidism compared with radiation to the breast and chest wall only [17] , [19] , [21] , [34] , with a pooled relative risk of 69 %, according to a recent meta -analysis [35] . Additionally, radiation-induced thyroid volume reduction [36] , [37] , [38] or a smaller thyroid volume was associated with a higher incidence of radiation-induced hypothyroidism [23] . Female sex [39] , [40] or systemic therapy [17] , [40] , [41] may also contribute to an increased risk.…”

Section: Discussionmentioning

confidence: 94%

Normal tissue complication probability models of hypothyroidism after radiotherapy for breast cancer

Park,

Cho,

Chang

et al. 2024

Clinical and Translational Radiation Oncology

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“…Clinical studies have reported alteration in TH levels [ 46 , 47 ] as well as shrinkage in thyroid gland size [ 78 ] in patients undergoing or following chemotherapy. Moreover, THs can enhance the efficacy of chemotherapy [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Rajagopalan

Chakraborty

Lin

2023

IJMS

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Noncoding RNAs are emerging as vital players in cardiovascular diseases. Thyroid hormones (THs) are crucial for cardiovascular survival; however, correction of systemic hypothyroidism (low serum THs) may not improve cardiac tissue-level hypothyroidism or cardiac function. Mechanistically, the understanding of noncoding transcriptomic interactions influencing TH-mediated cardiac effects is unclear. Adult C57BL/6J mixed-sex mice were randomized into Control, Hypothyroid (HypoTH), Hyperthyroid (HyperTH), and HypoTH-Triiodothyronine restoration groups. Physiological, morphological, biochemical, molecular, and whole transcriptomic studies and appropriate statistical analyses were performed. HypoTH showed significant atrophy, depressed cardiac function, and decreased serum THs versus controls, and Triiodothyronine supplementation restored them. HyperTH significantly increased serum THs with hypertrophy. Real-time PCR showed significantly altered inflammatory and immune lncRNAs. The transcriptomic sequencing revealed significant differential expressions of lncRNAs, miRNAs, and mRNAs. Eleven novel circRNAs significantly decreased with increased THs. Multiple pathways were GO-/KEGG-enriched, including cardiac, thyroid, cancer, mitochondrial, inflammatory, adrenergic, metabolic, immune-mediated, vesicular, etc. We also uncovered significant novel co-expression and interactions of lncRNA-miRNA, lncRNA-miRNA-mRNA, lncRNA-mRNA, circRNA-miRNA, and miRNA-mRNA, and splicing events. This includes a novel pathway by which the predominant cardiac TH receptor alpha may interact with specific lncRNAs and miRNAs. This is the first study reporting a comprehensive transcriptome-wide interactome in the cardiac–thyroid axis.

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Effect of chemoradiation on the size of the thyroid gland

Cited by 7 publications

References 15 publications

Thyroid volume changes following adjuvant radiation therapy for breast cancer

Thyroid volume changes following adjuvant radiation therapy for breast cancer

Normal tissue complication probability models of hypothyroidism after radiotherapy for breast cancer

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

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