Effect of Chemotherapy and Predictive Factors for Nausea or Vomiting in Patients with Cancer Receiving Opioid Analgesics for the First Time

Yamada, Masami; Matsumura, Chikako; Jimaru, Yumi; Ueno, Rie; Torii, Sari; Takahashi, Kunitaro; Yano, Yoshitaka

doi:10.2512/jspm.15.213

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Vomiting is a different event from nausea, as evidenced by the fact that patients with achalasia or Zenker diverticulum may regurgitate undigested food without nausea. 12) The occurrence of vomiting without nausea was observed in five cases in this study, all of which were associated with radiation therapy (data not shown). The cause of protruding vomiting, including sudden vomiting due to dietary stimulation, was considered to be more affected by the irritability of the head and neck and upper gastrointestinal tract associated with radiation therapy than with opioids.…”

Section: Discussionmentioning

confidence: 55%

Construction of a Risk Prediction Model of Extended Release Oxycodone Tablet-Induced Nausea and Clarification of Predictive Factors

Kumai

Imai

Kato

et al. 2021

Biological & Pharmaceutical Bulletin

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Nausea is a typical adverse event associated with opioids. In this study, we performed logistic regression analysis with the aim of clarifying the risk factors for nausea induced by extended-release oxycodone (ER-OXY). Furthermore, we constructed a decision tree (DT) model, a typical data mining method, to estimate the risk of oxycodone-induced nausea by combining multiple factors. A retrospective study was conducted on patients who newly received ER-OXY for cancer pain during hospitalization at Hokkaido University Hospital in Japan from April 2015 to March 2018. In logistic regression and DT analyses, the dependent variable was the presence or absence of nausea. Independent variables were the potential risk factors. First, univariate analyses were performed to screen potential factors associated with oxycodone-induced nausea. Then, multivariate and DT analyses were performed using factors with p-values <0.1 in the univariate analysis. Of 267 cases included in this study, nausea was observed in 30.3% (81/267). In multivariate logistic regression analysis, only female sex was extracted as an independent factor affecting nausea (odds ratio, 1.98). In the DT analysis, we additionally revealed that an age <50 years was a risk factor for nausea in female patients. Thus, our DT model indicated that the risk of ER-OXY-induced nausea was highest in the subgroup comprising females <50 years of age (66.7%) and lowest in male patients (25.1%). The DT model suggested that the factor of young women may be an increased risk of ER-OXY-induced nausea.

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Section: Discussionmentioning

confidence: 55%