Effect of Chemotherapy on Taste Sensation in Patients with Disseminated Malignant Melanoma

Mulder, Nanno; Smit, J. M.; Kreumer, W.M.I.; Bouman, Jan G.; Sleijfer, Dirk; Veeger, W; Koops, Schraffordt

doi:10.1159/000225687

Cited by 23 publications

(9 citation statements)

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“…Higher thresholds were found for bitter [85, 86], sweet [86, 87], sour [84, 86], and salty tastes [86]. However, in other studies changes or variations in sensitivity to different concentrations were not observed [82, 83]. Because these studies involved small sample sizes, these contradictory findings might be artefactual.…”

Section: Nutritional Complications Arising From Anti-cancer Therapiesmentioning

confidence: 99%

Protein calorie malnutrition, nutritional intervention and personalized cancer care

et al. 2017

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Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexiacachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass. Cachexia is defined as weight loss of more than 5% of body weight in 12 months or less in the presence of chronic disease. Hence with a chronic illness on board even a small amount of weight loss can open the door to cachexia. These nutritional challenges can lead to severe morbidity and mortality in cancer patients. In the clinic, the application of personalized medicine and the ability to withstand the toxic effects of anti-cancer therapies can be optimized when the patient is in nutritional homeostasis and is free of anorexia and cachexia. Routine assessment of nutritional status and appropriate intervention are essential components of the effort to alleviate effects of malnutrition on quality of life and survival of patients.

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Section: Nutritional Complications Arising From Anti-cancer Therapiesmentioning

confidence: 99%

Protein calorie malnutrition, nutritional intervention and personalized cancer care

et al. 2017

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“…Den vanligast använda metoden är att presentera patienten för olika koncentrationer av de fyra grundsmakerna salt, surt, sött eller bittert. Det ger svar på vilken koncentration av grundsmaken som behövs för att individen ska upptäcka att det smakar något (tröskelvärdet) samt vilken koncentration som behövs för att individen ska kunna identifiera smaken (identifikationstest) (11,76,84). Ännu har inget standardiserat test av den femte grundsmaken umami rapporterats.…”

Section: Testning Av Smak-och Luktförmåganunclassified

“…Mulder et al (84) undersökte patienter diagnostiserade med maligna melanom som behandlades med cytostatika. De fann att lägre koncentrationer av sött, salt och surt skattades ha en högre intensitet efter cytostatikabehandlingen än innan.…”

Section: Testning Av Smak-och Luktförmåganunclassified

Taste and Smell Changes in Patients Receiving Cancer Chemotherapy

2009

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Few studies have described how patients receiving chemotherapy experience taste/smell changes (TSCs). Food and meal situations have important meaning beyond nutrition, so these common symptoms may affect daily lives. This study aims to investigate distress and impact on daily life from TSCs in patients receiving cancer chemotherapy, analyze reported levels of distress and impact on daily life from TSCs with regard to sociodemographic and clinical factors, and explore patients' reports of self-care strategies and communication with staff. The 340 patients reporting TSCs on a multicenter survey (n = 518) were grouped into subsets by level of TSC-related distress and impact on daily life, which served as the basis for statistical comparison. Written comments were analyzed inductively using content analysis. Nearly one-third of participating patients reported both high levels of distress and impact on daily life (high distress and high impact on daily life [HDHI]) from TSCs. The HDHI subset reported other symptoms more often than others did (P = .01) and also more often responded to open questions about distress, impact, and self-care strategies (P = .01). Taste/smell changes were not always reported to staff, even in the HDHI subset. The specific aspects of TSCs resulting in distress and impact on daily life varied greatly, affecting both psychological and somatic aspects, with little consensus and great individual differences described in self-care strategies. The variety of distress, impact, and strategies used to alleviate TSCs clarifies the importance of situational meaning.

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“…The few studies that have investigated TSCs among patients receiving cancer chemotherapy have focused on physiological tests of taste and smell sensitivity [3,19,21] or prevalence of disturbance [10,25] rather then on how these chemosensory changes affect patients' daily lives. While such physiological knowledge is important in developing approaches to prevent or treat disturbances, knowledge about patients' experiences of TSCs is also needed to enable support during chemotherapy.…”

Section: Introductionmentioning

confidence: 99%