Effect of chemotherapy with 5-fluorouracil on intestinal permeability of patients with advanced colon cancer

Daniele, Bruno; Secondulfo, Mario; Pignata, Sandro; Martino, S; Magistris, Laura de; Vivo, Rocco De; M, Pergola; D’Agostino, Luciano; Monfardini, S.; Carratù, R.

doi:10.1016/s0959-8049(97)85385-3

Cited by 2 publications

(3 citation statements)

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“…The CE/MA test procedure has been proposed by Strobel et al (13) as a relatively convenient tool in the study of intestinal permeability and has since been used by other investigators (14‐18). In our laboratory it was reliable with no substantial flaws in healthy children and adults; in diseases such as scleroderma (21), radiation enteritis (19‐20), cancer chemotherapy (23), postcolectomy pouch (24), and in type II diabetes mellitus (30). The increase of the ratio, which has been shown in different pathologic conditions such as celiac disease (14,16,17), malnutrition (31), iron deficiency (32), idiopathic and infectious diarrhea (33), food allergy (18), cystic fibrosis (15), and Crohn's disease (34‐35), was not reproduced in our patients with IDDM.…”

Section: Discussionmentioning

confidence: 99%

“…To define normal values of the cellobiose‐mannitol (CE/MA) permeability test (13‐24) in our laboratory, 12 healthy children were compared with the patients. Sex and age allocation: 7 girls, 5 boys; mean age, 13.08 ± 2.88 years.…”

Section: Methodsmentioning

confidence: 99%

“…The purpose of the present investigation was to search in children, adolescents, and young adults with uncomplicated IDDM for alterations of intestinal permeability to two different sized sugar probes, cellobiose and mannitol, that have different permeability pathways and are easily and reliably measured in urine (13‐24). Unless stated differently, values are mean ± standard error (SE).…”

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confidence: 99%

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Altered Intestinal Permeability to Mannitol in Diabetes Mellitus Type I

Carratù,

Secondulfo,

de Magistris

et al. 1999

J. pediatr. gastroenterol. nutr.

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Background:Intestinal permeability has seldom been investigated in diabetes mellitus, even though patients frequently report gastrointestinal symptoms, and it has recently been shown that the prevalence of celiac disease associated with diabetes mellitus is higher than expected.Methods:Intestinal permeability to cellobiose and mannitol was investigated in 31 patients affected by type I uncomplicated diabetes mellitus. Values were compared with those obtained in 32 normal subjects.Results:The percentage of mannitol recovery was far higher than normal in two thirds of the investigated patients and correlated with the length of disease, even though the probes' ratio (cellobiose/mannitol) was in the normal range.Conclusions:A not previously reported increase of intestinal permeability to mannitol, clear‐cut and not associated with that of the larger probe, is found in type I uncomplicated diabetes mellitus. These results may describe a primary feature of type I diabetes mellitus and the initial steps of evolution of celiac disease.

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