Effect of childhood obesity on admissions for respiratory disease

Ogino, Jayme; Basravi, Sunniya; Salazar, Adler; Chan, Randall Y.

doi:10.1111/apa.16177

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…As for the mean duration of mechanical ventilation, compared to previous reports with a duration varying from 2–7 to 21−28 days, our cohort reported a mean of 9.57 days of ventilation 31 . It has been well‐described that obesity is an inflammatory state of malnutrition that can impact disease severity and outcomes, especially in adults 32–34 . In our cohort it was found to increase the risk of OTI and IMV (RR = 1.73, 95% CI: [1.10−2.72], p = 0.017).…”

Section: Discussionsupporting

confidence: 46%

“…31 It has been well-described that obesity is an inflammatory state of malnutrition that can impact disease severity and outcomes, especially in adults. [32][33][34] In our cohort it was found to increase the risk of OTI and IMV (RR = 1.73, 95% CI: [1.10−2.72], p = 0.017). In other series, it has been shown to increase the time of OTI but not necessarily increase mortality in patients with ARI and ARF, such as in our cohort.…”

Section: Oti and Imvmentioning

confidence: 54%

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Severity and mortality of acute respiratory failure in pediatrics: A prospective multicenter cohort in Bogotá, Colombia

Vargas‐Acevedo,

Botero Marín,

Jaime Trujillo

et al. 2024

Health Science Reports

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Background and AimsAcute respiratory failure (ARF) is the most frequent cause of cardiorespiratory arrest and subsequent death in children worldwide. There have been limited studies regarding ARF in high altitude settings. The aim of this study was to calculate mortality and describe associated factors for severity and mortality in children with ARF.MethodsThe study was conducted within a prospective multicentric cohort that evaluated the natural history of pediatric ARF. For this analysis three primary outcomes were studied: mortality, invasive mechanical ventilation, and pediatric intensive care unit (PICU) length of stay. Eligible patients were children older than 1 month and younger than 18 years of age with respiratory difficulty at the time of admission. Patients who developed ARF were followed at the time of ARF, 48 h later, at the time of discharge, and at 30 and 60 days after discharge. It was conducted in the pediatric emergency, in‐hospital, and critical‐care services in three hospitals in Bogotá, Colombia, from April 2020 to June 2021.ResultsOut of a total of 685 eligible patients, 296 developed ARF for a calculated incidence of ARF of 43.2%. Of the ARF group, 90 patients (30.4%) needed orotracheal intubation, for a mean of 9.57 days of ventilation (interquartile range = 3.00–11.5). Incidence of mortality was 6.1% (n = 18). The associated factors for mortality in ARF were a history of a neurologic comorbidity and a higher fraction of inspired oxygen at ARF diagnosis. For PICU length of stay, the associated factors were age between 2 and 5 years of age, exposure to smokers, and respiratory comorbidity. Finally, for mechanical ventilation, the risk factors were obesity and being unstable at admission.ConclusionsARF is a common cause of morbidity and mortality in children. Understanding the factors associated with greater mortality and severity of ARF might allow earlier recognition and initiation of prompt treatment strategies.

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Section: Discussionsupporting

confidence: 46%

Section: Oti and Imvmentioning

confidence: 54%

Severity and mortality of acute respiratory failure in pediatrics: A prospective multicenter cohort in Bogotá, Colombia

Vargas‐Acevedo,

Botero Marín,

Jaime Trujillo

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…As for the mean duration of mechanical ventilation, compared to previous reports with a duration varying from 2-7 days to 21-28 days, our cohort reported a mean of 9.57 days of ventilation (28). It has been well-described that obesity is an in ammatory state of malnutrition that can impact disease severity and outcomes, especially in adults (29)(30)(31). In our cohort it was found to increase the risk of OTI and IMV (RR = 1.73, 95% CI [1.10, 2.72], p = .017).…”

Section: Oti and Imvmentioning

confidence: 48%

Severity and Mortality of Acute Respiratory Failure in Pediatrics: A Prospective Cohort at 2,600 Meters Above Sea Level

Vargas-Acevedo

Marín

Trujillo

et al. 2023

Preprint

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Background: Acute respiratory failure (ARF) is the most frequent cause of cardiorespiratory arrest and subsequent death in children worldwide, therefore several efforts have been made to better understand its etiology and risk factors for further progression (1–4). The aim of this study was to calculate mortality and describe associated factors for severity and mortality in children with acute respiratory failure. Methods: The study was conducted within a prospective multicentric cohort that evaluated the natural history of pediatric acute respiratory failure (ARF). For this analysis three primary outcomes were studied: mortality, invasive mechanical ventilation, and pediatric intensive care unit length of stay. Setting: Pediatric emergency, in-hospital, and critical care services in three hospitals in Bogotá, Colombia, from April 2020 to June 2021. Patients: Eligible patients were children older than 1 month and younger than 18 years of age with respiratory difficulty at time of admission. Patients who developed ARF were followed at time of ARF, 48 hours later, at time of admission and at 30 and 60 days after discharge. Measurements and main results: Out of a total of 685 eligible patients, 296 developed ARF for a calculated incidence of ARF of 43.2%. Of the ARF group, ninety patients (30.4%) needed orotracheal intubation, for a mean of 9.57 days of ventilation (interquartile range = 3.00–11.5). Incidence of mortality was 6.1% (n= 18). The associated factors for mortality in ARF were a history of a neurologic comorbidity and a higher fraction of inspired oxygen at ARF diagnosis. For PICU length of stay associated factors were age between 2 and 5 years of age, exposure to smokers, and respiratory comorbidity. Finally, for mechanical ventilation, the risk factors were obesity and being unstable at admission. Conclusions: ARF is a common cause of morbidity and mortality in children. Understanding the factors associated with greater mortality and severity of ARF might allow earlier recognition and initiation of prompt treatment strategies.

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Effect of childhood obesity on admissions for respiratory disease

Cited by 2 publications

References 19 publications

Severity and mortality of acute respiratory failure in pediatrics: A prospective multicenter cohort in Bogotá, Colombia

Severity and mortality of acute respiratory failure in pediatrics: A prospective multicenter cohort in Bogotá, Colombia

Severity and Mortality of Acute Respiratory Failure in Pediatrics: A Prospective Cohort at 2,600 Meters Above Sea Level

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