Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

Sugaya, Akira; Tsuda, Tadashi; Obuchi, Tadashi; Sugaya, Eiichi

doi:10.1055/s-2007-969951

Cited by 13 publications

(3 citation statements)

References 5 publications

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“…Magnolia bark has been extensively used as Chinese folklore medicine and is still in use in modern clinical practices [41,42,43,44,45]. Magnolia trees have striking features like their alluring flowers with fragrance, and petiolate leaves containing large stipules surround the stem and later fall, leaving a distinctive scar around the node; the wood of the tree is tough, light weight and easy to work, and is sought after by craftsmen [46].…”

Section: Introductionmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

138

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The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

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Section: Introductionmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

138

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“…Reflex responses to electrical stimulation were recorded in the laryngeal nerves of cats. After a single administration of HKT, the response gradually decreased, disappeared, and then gradually recovered [59].…”

Section: Kampo Extract Formulation Administration Amount and Duration...mentioning

confidence: 99%

“…After a single administration of HKT, the spontaneous locomotor activity of mice decreased, especially during the dark period. The treatment also prolonged the sleep time of hexobarbital‐treated mice [59].…”

Section: Kampo Extract Formulation Administration Amount and Duration...mentioning

confidence: 99%

A review of frequently used Kampo prescriptions: Part 2—Hangekobokuto

Suzuki

Kikuchi

Arita

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe origin of hangekobokuto (HKT) is from Jin Gui Yao Lue (Kinkiyōryaku in Japanese), and it has been indicated for treating throat discomfort in women.Key FindingsHKT consists of five crude drugs. Clinical studies have shown that HKT can improve the swallowing reflex by increasing the substance P level in saliva; improve the cough reflex; reduce pneumonia in patients with dementia, cerebrovascular disease, Alzheimer's disease, or Parkinson's disease; reduce postoperative aspiration pneumonia in patients who undergo cardiovascular surgery; and improve depression and anxiety scores in patients with globus hystericus. Furthermore, HKT has been reported to increase serotonin (5‐HT) and noradrenaline levels in the hypothalamus, and dopamine (DA) levels in the striatum in a healthy rodent model; improve 5‐HT levels in the striatum and hippocampus, and ameliorate 5‐HT and DA reductions in the whole brain in an acute stress model; improve 5‐HT levels in the striatum, and ameliorate 5‐HT and DA reductions in the prefrontal cortex in a chronic stress model; and decrease corticosterone and corticotropin‐releasing factor levels in a chronic stress model. Reported adverse events of HKT include interstitial pneumonia (0.38 per 100 000 cases) and liver damage (0.89 per 100 000 cases), which are rare.ConclusionHKT is widely used and shows a low rate of adverse events. Several clinical studies have reported its effects in reducing aspiration pneumonia and improving depression and anxiety, some of which may be explained by the regulation of monoamines and stress hormones in the brain and substance P levels in the oral cavity.

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Zingiber officinale

Medicinal Plants of the World, Volume 3

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Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

Cited by 13 publications

References 5 publications

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

A review of frequently used Kampo prescriptions: Part 2—Hangekobokuto

Zingiber officinale

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