Effect of Chinese herbs on CYP3A4 activity and expression in vitro

Lau, Cedric; Mooiman, Kim D.; Maas-Bakker, Roel F.; Beijnen, Jos H.; Schellens, Jan H.M.; Meijerman, Irma

doi:10.1016/j.jep.2013.07.014

Cited by 48 publications

(22 citation statements)

References 33 publications

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“…Meanwhile, most herbal medicines are usually prescribed in combination in clinical application, in order to obtain the synergistic effects or to reduce the possible side effects, which are difficult to Western medicines [53]. HLJDD is a popular formula of TCM, which consist of 4 herbs.…”

Section: Discussionmentioning

confidence: 99%

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Nie

Deng

Xiang

et al. 2016

BMC Complement Altern Med

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BackgroundHuang Lian Jie Du Decoction (HLJDD), a very famous traditional Chinese medicinal prescription, has been used for heat dissipation and detoxification in China. This study was aimed to evaluate the reno-protective effects of HLJDD against lupus nephritis (LN) in vivo in MRL/lpr mice.MethodsAnimals were administered orally every day for eight consecutive weeks except the mice of normal group and model group. Organ indexes, serum interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-gamma (IFN-γ) and the anti-double stranded DNA (anti-dsDNA) antibody were tested, respectively. Creatinine (Cr), blood urea nitrogen (BUN) and urine protein were measured for renal function evaluation. The expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT 3) in kidney tissue was observed by western blot (WB) and immunohistochemical (IHC) method. Meanwhile, histopathological changes in the renal were studied by hematoxylin-eosin (H&E) staining.ResultsThe mice of HLJDD-treated group exhibited a significant reduced mortality (p < 0.05), serum anti-dsDNA level (p < 0.05) and renal immune complex deposition (p < 0.05), compared with the untreated MRL/lpr mice. In addition, HLJDD treatment remarkably reduced the levels of BUN, Cr, proteinuria (p < 0.01) and the levels of inflammatory cytokines such as IL-6, IL-10 and IFN-γ (p < 0.01). Moreover, HLJDD significantly suppressed the phosphorylations of STAT 3 (p < 0.05) and the renal pathological changes.ConclusionsThe study implied that HLJDD may be a potential agent for the therapy of LN, and the down-regulated p-STAT 3 expression suggesting that it may be one of the LN therapy targets for HLJDD.

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Section: Discussionmentioning

confidence: 99%

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Nie

Deng

Xiang

et al. 2016

BMC Complement Altern Med

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“…However, this formula was also reported to attenuate the anti-proliferative activity of trastuzumab by increasing the phosphorylation of the cell cycle regulatory protein p27 (Kip1) [115]. A combination of Baihuasheshecao and Dihuang was reported to inhibit the expression of CYP3A4, another drug antiporter, consequently increasing the potential toxicity of drugs and narrowing the therapeutic window [116]. More examples were listed in Table 4 .…”

Section: Unwanted Side Effects Of Synergistic Combinationsmentioning

confidence: 99%

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

Hu¹,

Sun²,

Lau³

et al. 2016

CCDT

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The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms of enhancing efficacy, reducing side effects, immune modulation, as well as abrogating drug resistance. Our conclusions support the development of further science-based holistic modalities for cancer care.

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“…The research has focused primarily on the effects of herbal components on the induction and bioavailability of chemotherapy agents, and is almost exclusively preclinical, in which cancer cell lines and animal models are exposed to combinations of herbal products and chemotherapeutic agents . The potential for herb‐drug interactions is attributed primarily to the drug‐metabolizing enzyme cytochrome P450 (CYP450) system, of which CYP3A4 is the most predominant . Other factors such as the transporter P‐glycoprotein have been examined as well .…”

Section: Introductionmentioning

confidence: 99%

Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals

Ben‐Arye

Samuels

Goldstein

et al. 2015

Cancer

113

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BACKGROUND The authors assessed the use of herbal medicine by Middle Eastern patients with cancer, as reported by their oncology health care professionals (HCPs). Herbal products identified by the study HCPs were evaluated for potential negative effects. METHODS Oncology HCPs from 16 Middle Eastern countries received a 17‐item questionnaire asking them to list 5 herbal products in use by their patients with cancer. A literature search (PubMed, Micromedex, AltMedDex, and the Natural Medicine Comprehensive Database) was conducted to identify safety‐related concerns associated with the products listed. RESULTS A total of 339 HCPs completed the study questionnaire (response rate of 80.3%), identifying 44 herbal and 3 nonherbal nutritional supplements. Safety‐related concerns were associated with 29 products, including herb‐drug interactions with altered pharmacodynamics (15 herbs), direct toxic effects (18 herbs), and increased in vitro response of cancer cells to chemotherapy (7 herbs). CONCLUSIONS Herbal medicine use, which is prevalent in Middle Eastern countries, has several potentially negative effects that include direct toxic effects, negative interactions with anticancer drugs, and increased chemosensitivity of cancer cells, requiring a reduction in dosedensity. Oncology HCPs working in countries in which herbal medicine use is prevalent need to better understand the implications of this practice. The presence of integrative physicians with training in complementary and traditional medicine can help patients and their HCPs reach an informed decision regarding the safety and effective use of these products. Cancer 2016;122:598–610. © 2015 American Cancer Society.

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Effect of Chinese herbs on CYP3A4 activity and expression in vitro

Cited by 48 publications

References 33 publications

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals

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