Effect of chitosan coating on the characteristics of DPPC liposomes

Mady, Mohsen M.; Darwish, M.

doi:10.1016/j.jare.2010.05.008

Cited by 93 publications

(47 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The zeta potential (f) of particles was stable due to the repulsion between vesicles by the increase of the surface electrical charge (Mady and Darwish, 2010). In the zeta potential analysis, liposomes positively or negatively charged showed values higher than 30 mV (module).…”

Section: Discussionmentioning

confidence: 99%

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cury¹,

Yoneda²,

Zuliani³

et al. 2015

Journal of Microencapsulation

View full text Add to dashboard Cite

Synthetic compounds derived from cinnamic acid were tested in cultures containing the promastigote form of Leishmania amazonensis and the dimethylsulphoxide solution of B2 compound (2.0 mg/mL) led to a 92% decrease of leishmania in 96 h of treatment. Then, different liposomal systems (diameters ∼200 nm) were prepared by the extrusion method in the presence and absence of compounds studied. DSC thermograms of the liposomes in the presence of these compounds caused changes in ΔH, Tm and ΔT1/2, compared to controls, indicating that there was an interaction of the compounds with the lipid bilayer. Assays with negatively charged liposomal systems containing these drugs in L. amazonensis cultures led to a 50-80% decrease in the number of leishmanias with a concentration to 100 times lower when compared to the B2 initial test. These liposomal systems are promoting more interaction and delivery of the compounds and proved to be an efficient, stable and promising system.

show abstract

Section: Discussionmentioning

confidence: 99%

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cury¹,

Yoneda²,

Zuliani³

et al. 2015

Journal of Microencapsulation

View full text Add to dashboard Cite

show abstract

“…The Dv 50 obtained with ALs in the conventional device was very close to that obtained with the VP3 device. However, a significant increase in Dv 50 and Dv 4,3 was observed for HTCC-ALs from the conventional device, showing droplets more than twice as large (Dv 50 of 40.41±2.78 and 95.36±9.57 µm with ALs and HTCC-ALs, respectively). The potential viscosity afforded by HTCC could be responsible for this evolution, as has been already observed in another study.…”

mentioning

confidence: 90%

“…The nasal administration of peptide with such formulation strategies has already shown interesting properties (also with other administration routes). 49,50 The HTCC-concentration range used after dilution in the AL suspensions for the coating was fixed between 1 mg/mL and 5 mg/mL. 51 Higher HTCC concentrations (.1 mg/mL) did not provide satisfactory results with a PDI larger than 0.198 (data not shown).…”

Section: Htcc-coated Liposomesmentioning

confidence: 99%

Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

Salade¹,

Wauthoz²,

Deleu³

et al. 2017

IJN

View full text Add to dashboard Cite

The aim of the present study was to develop a ghrelin-containing formulation based on liposomes coated with chitosan intended for nose–brain delivery for the treatment of cachexia. Among the three types of liposomes developed, anionic liposomes provided the best results in terms of encapsulation efficiency (56%) and enzymatic protection against trypsin (20.6% vs 0% for ghrelin alone) and carboxylesterase (81.6% vs 17.2% for ghrelin alone). Ghrelin presented both electrostatic and hydrophobic interactions with the anionic lipid bilayer, as demonstrated by isothermal titration calorimetry. Then, anionic liposomes were coated with N -(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride. The coating involved a size increment from 146.9±2.7 to 194±6.1 nm, for uncoated and coated liposomes, respectively. The ζ-potential was similarly increased from -0.3±1.2 mV to 6±0.4 mV before and after coating, respectively. Chitosan provided mucoadhesion, with an increase in mucin adsorption of 22.9%. Enhancement of permeation through the Calu3 epithelial monolayer was also observed with 10.8% of ghrelin recovered in the basal compartment in comparison to 0% for ghrelin alone. Finally, aerosols generated from two nasal devices (VP3 and SP270) intended for aqueous dispersion were characterized with either coated or uncoated liposomes. Contrarily to the SP270 device, VP3 device showed minor changes between coated and uncoated liposome aerosols, as shown by their median volume diameters of 38.4±5.76 and 37.6±5.74 µm, respectively. Overall, the results obtained in this study show that the developed formulation delivered by the VP3 device can be considered as a potential candidate for nose–brain delivery of ghrelin.

show abstract

“…Chitosan-coated liposomes (so-called chitosomes) were previously prepared by several authors and their effective formation was confirmed using several techniques such as SEM and TEM (11,14,(41)(42)(43).…”

Section: Preparation and Characterizationmentioning

confidence: 99%

Improving Oral Bioavailability and Pharmacokinetics of Liposomal Metformin by Glycerolphosphate–Chitosan Microcomplexation

et al. 2013

View full text Add to dashboard Cite

Abstract. The purpose of this study was to develop a new delivery system capable of improving bioavailability and controlling release of hydrophilic drugs. Metformin-loaded liposomes were prepared and to improve their stability surface was coated with chitosan cross-linked with the biocompatible β-glycerolphosphate. X-ray diffraction, differential scanning calorimetry, as well as rheological analysis were performed to investigate interactions between chitosan and β-glycerolphosphate molecules. The entrapment of liposomes into the chitosan-β-glycerolphosphate network was assessed by scanning electron microscopy and transmission electron microscopy. Swelling and mucoadhesive properties as well as drug release were evaluated in vitro while the drug oral bioavailability was evaluated in vivo on Wistar rats. Results clearly showed that, compared to control, the proposed microcomplexes led to a 2.5-fold increase of metformin T max with a 40% augmentation of the AUC/D value.

show abstract

Effect of chitosan coating on the characteristics of DPPC liposomes

Cited by 93 publications

References 44 publications

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

Improving Oral Bioavailability and Pharmacokinetics of Liposomal Metformin by Glycerolphosphate–Chitosan Microcomplexation

Contact Info

Product

Resources

About