Effect of Chitosan Structure and Deposition Time on Structural and Mechanical Properties of Chitosan-Hydroxyapatite Tubular-Shaped Electrodeposits for Biomedical Applications

Nawrotek, Katarzyna; Grams, Jacek; Sobczyk, Robert; Kubicka, Monika; Czeladzińska, Beata; Jóźwiak, Piotr

doi:10.2139/ssrn.4368203

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“…203 A polyelectrolyte construct composed of high molecular ascorbate of chitosan, chondroitin sulfate, sodium hyaluronate, heparin, serum growth factor, sodium alginate, and nano-HAp was used to increase the efficiency of early bone formation in a critical size in diabetes mellitus. 204 Studies were conducted on five groups of white female Wistar rats: group 1 -regeneration of a bone defect in healthy animals under a blood clot; group 2 -regeneration of a bone defect under a blood clot in animals with diabetes mellitus; group 3 -bone regeneration in animals with diabetes mellitus after filling the bone cavity with a collagen sponge; group 4 -filling of a bone defect with a chitosan@sodium alginate@HAp complex in healthy animals; group 5 -filling of a bone defect with a chitosan@sodium alginate@HAp construct in animals with diabetes mellitus. Chitosan@sodium alginate@HAp cosntruct in diabetes mellitus created a high efficiency of bone regeneration and significantly compensates for the level of osteogenesis (Figure 15).…”

Section: Applications 2321 Drug Adsorption and Drug Carriermentioning

confidence: 99%

Polysaccharide Hydroxyapatite (Nano)composites and Their Biomedical Applications: An Overview of Recent Years

Costa,

Félix Farias,

Silva-Filho

et al. 2024

ACS Omega

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Hydroxyapatite can combine with polysaccharide originating biomaterials with special applications in the biomedical field. In this review, the synthesis of (nano)composites is discussed, focusing on natural polysaccharides such as alginate, chitosan, and pectin. In this way, advances in recent years in the development of preparing materials are revised and discussed. Therefore, an overview of the recent synthesis and applications of polyssacharides@ hydroxyapatites is presented. Several studies based on chitosan@ hydroxyapatite combined with other inorganic matrices are highlighted, while pectin@hydroxyapatite is present in a smaller number of reports. Biomedical applications as drug carriers, adsorbents, and bone implants are discussed, combining their dependence with the nature of interactions on the molecular scale and the type of polysaccharides used, which is a relevant aspect to be explored.

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Section: Applications 2321 Drug Adsorption and Drug Carriermentioning

confidence: 99%