Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats

Santhosh, Sethumadhavan; Sini, Theruvathil K.; Anandan, R.; Mathew, P. M.

doi:10.1016/j.tox.2005.11.001

Cited by 88 publications

(55 citation statements)

References 33 publications

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“…Thus, the overall hepatoprotective effect of chitosan is probably due to a counteraction of free radicals by its antioxidant nature and/or to its ability to inhibit lipid accumulation by its antilipidemic property [95] [96]. Santhosh et al [97] showed that co-treatment with chitosan may prevent antitubercular drugs-induced hepatotoxicity in rats. Moreover, chitosan was also effective against TCDD-induced hepatotoxicity which is persistent and highly toxic environmental pollutants [98].…”

Section: Discussionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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Section: Discussionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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“…42 Various studies proved the successful use of rat's models for INH and RMP induced hepatotoxicity. 11,43 Therefore, same model has been used to determine the hepatoprotective activity of CP in the anti-TB drug-induced toxicity. INH and RMP were given daily for 14 days to produce liver toxicity at very high doses (INH 50 mg/kg, RMP 100 mg/kg) as compared with humans because rats metabolize drugs faster than humans and period of study shorter in comparison to the treatment of TB in humans.…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Kamil¹,

Imran-ul-Haque²

2014

Phcog J.

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Objective: In this study anti-tubercular (Anti-TB) drugs (isoniazid [INH] and rifampicin [RMP]) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of Calotropis procera (CP) fl owers in rats. Materials and Methods: Animals were divided into four groups, group A was given normal saline (1 ml/kg), group B received INH (50 mg/kg) and RMP (100 mg/kg) group C received INH (50 mg/kg), RMP (100 mg/kg) and CP (150 mg/kg) orally for 14 days. Results: Biochemical markers of liver toxicity such as aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin and tissue histology were done inall groups. Anti-TB drugs (INH 50 mg/kg and RMP 100 mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with CP has reduced these levels within the normal range. Conclusion: Findings of this study showed the hepatoprotective effect of CP against INH and RMP administration to reduce the liver damage for chronic treatment.

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“…Elevated levels of these enzymes in serum are presumptive markers of drug induced necrotic lesions in the hepatocytes [32] . Enhanced susceptibility of hepatocytes cell membrane to antitubercular drugs induced peroxidative damage might have resulted in increased release of these diagnostic marker enzyme levels into the systemic circulation [33] . The activity of ALT and AST are sensitive indicators of acute hepatic necrosis, and the ALP level is known to be indicative of hepatobilliary disease [34] .…”

Section: Discussionmentioning

confidence: 99%

Anti-hepatotoxic and antioxidant influence of Ipomoea carnea against anti-tubercular drugs induced acute hepatopathy in experimental rodents

2013

JCLM

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Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats

Cited by 88 publications

References 33 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Anti-hepatotoxic and antioxidant influence of Ipomoea carnea against anti-tubercular drugs induced acute hepatopathy in experimental rodents

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