Effect of chlorambucil and indomethacin on growth and prostaglandin levels in sensitive and resistant walker carcinoma

Tisdale, Michael J.; Gibbs, John F.; Dobrzanski, R.J.

doi:10.1016/0009-2797(82)90123-5

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…synthesis (P<o.o5) while concentrations of 1 x M of prostaglandins (usually E series) in the culture had a statistically insignificant effect. The slope of all medium of proliferating cells with increasing cell the curves is similar, indicating that daily administra-number (Taylor and Polgar, 1981;Thomas etal., 1974; tion of indomethacin results in continuous inhibition Of Tisdale et 1982). Hang et al (1976) report that PGE release.…”

Section: In Culturementioning

confidence: 99%

Effects of indomethacin on the growth of cultured mammary tumors

Fulton¹

1984

Intl Journal of Cancer

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We have studied the relative prostaglandin E (PGE) synthesizing abilities of a number of mammary tumor lines cultured in vitro. These lines differ in a number of biologic characteristics including tumorigenicity, immunogenicity and metastatic potential. They also synthesize different levels of PGE and these levels are in the same relative order as seen in situ. The metastatic tumor lines 4526 and 410.4 synthesize more PGE than does the non-metastatic tumor line 410. Synthetic activity of all lines decreases with time in culture. Relative synthetic capacity is not correlated with cell doubling time as the highest PGE levels are seen with the slowest growing (68H) and fastest growing (4526) cell lines. Indomethacin is able to inhibit the synthesis of PGE in vitro in a dose-dependent manner and the presence of indomethacin results in stimulation of cell division.

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Section: In Culturementioning

confidence: 99%