Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials

Fallah, Aziz A.; Sarmast, Elham; Dehkordi, Saied Habibian; Engardeh, Javad; Mahmoodnia, Leila; Khaledifar, Arsalan; Jafari, Tina

doi:10.1016/j.clnu.2017.09.019

Cited by 61 publications

(26 citation statements)

References 50 publications

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“…The levels of various lipid profiles like TC, TG, and HDL‐c were moderately altered in the CWE group, but only the levels of LDL‐c were significantly lowered after 3 months of treatment with CWE. The above results are in concordance with the results of a recent meta‐analysis study conducted by Fallah and others (2018). Moreover, the activities of hepatic markers like GPT and GOT were considerably lowered upon administration with CWE.…”

Section: Discussionsupporting

confidence: 92%

Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

et al. 2021

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The current study aims to explore the anti-inflammatory activity of Chlorella pyrenoidosa on RAW 267.4 cells and followed by a cross-over clinical trial in healthy subjects to check the antioxidant and anti-aging properties of Chlorella water extract (CWE).For the clinical trial, 44 healthy subjects were requested to consume 27 ml of either placebo or CWE for 90 days (phase I) and vice-versa manner for 90 days (phase II) with 4 weeks of washout period. The RAW 264.7 macrophages treated with Chlorella display potent anti-inflammatory activity by significantly downregulating (p < .05) the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Whereas, the subjects supplemented with CWE showed improved (p < .05) antioxidant status (TEAC, SOD, CAT, and DHEAs) and lower (p < .05) oxidative stress/aging markers (TBARS and 8-OHdG) as well as considerably (p < .05) protected liver (by lowering GOT and GPT). Thus, consumption of chlorella could significantly improve the overall health status by suppressing various oxidative stress markers and aging stress markers.

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Section: Discussionsupporting

confidence: 92%

Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

et al. 2021

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“…The effects of microalgae supplementation on humans have been studied previously [ 9 , 10 ], and marine bioactive peptides from microalgae have shown therapeutic potential in the treatment or prevention of disease [ 11 ]. The different effects of microalgae supplementation are anti-inflammatory [ 12 ], antioxidant [ 13 ], hypotensive [ 14 ] and hypolipidemic [ 15 ], among others. Supplementation with some microalgae such as spirulina and chlorella has been well studied [ 16 , 17 ]; however, the effect of supplementation with Tetraselmis chuii (TC) is unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of Tetraselmis chuii Microalgae Supplementation on Ergospirometric, Haematological and Biochemical Parameters in Amateur Soccer Players

Toro

Siquier-Coll

Bartolomé

et al. 2020

IJERPH

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This study aimed to analyse the effects of Tetraselmis chuii (TC) microalgae supplementation during thirty days on ergospirometric, haematological and biochemical parameters in amateur soccer players. Thirty-two amateur soccer players divided into a control group (CG; n = 16; 22.36 ± 1.36 years; 68.36 ± 3.53 kg) and a supplemented group (SG; n = 16; 22.23 ± 2.19 years; 69.30 ± 5.56 kg) participated in the double-blind study. SG ingested 200 mg of the TC per day, while CG ingested 200 mg per day of lactose powder. Supplementation was carried out for thirty days. The participants performed a maximal treadmill test until exhaustion. The ergospirometric values at different ventilatory thresholds and haematological values were obtained after the test. Heart rate decreased after supplementation with TC (p < 0.05). Oxygen pulse, relative and absolute maximum oxygen consumption increased in SG (pre vs. post; 19.04 ± 2.53 vs. 22.08 ± 2.25; 53.56 ± 3.26 vs. 56.74 ± 3.43; 3.72 ± 0.35 vs. 3.99 ± 0.25; p < 0.05). Haemoglobin and mean corpuscular haemoglobin increased in SG (pre vs. post; 15.12 ± 0.87 vs. 16.58 ± 0.74 p < 0.01; 28.03 ± 1.57 vs. 30.82 ± 1.21; p < 0.05). On the other hand, haematocrit and mean platelet volume decreased in SG (p < 0.05). TC supplementation elicited improvements in ergospirometric and haematological values in amateur soccer players. TC supplementation could be valuable for improving performance in amateur athletes.

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“…The efficacy of Chlorella supplementation in reducing cardiovascular risk factors was assessed in a meta-analysis of 19 randomized controlled trials including 797 subjects [95]. This study concluded that Chlorella supplementation improves total cholesterol levels, low-density lipoprotein cholesterol levels, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels but not triglyceride levels, high-density lipoprotein cholesterol levels, and body mass index.…”

Section: Antihypertensive Effectsmentioning

confidence: 99%

Potential of Chlorella as a Dietary Supplement to Promote Human Health

Bito

Okumura²,

Fujishima³

2020

Nutrients

155

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Chlorella is a green unicellular alga that is commercially produced and distributed worldwide as a dietary supplement. Chlorella products contain numerous nutrients and vitamins, including D and B12, that are absent in plant-derived food sources. Chlorella contains larger amounts of folate and iron than other plant-derived foods. Chlorella supplementation to mammals, including humans, has been reported to exhibit various pharmacological activities, including immunomodulatory, antioxidant, antidiabetic, antihypertensive, and antihyperlipidemic activities. Meta-analysis on the effects of Chlorella supplementation on cardiovascular risk factors have suggested that it improves total cholesterol levels, low-density lipoprotein cholesterol levels, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels but not triglycerides and high-density lipoprotein cholesterol levels. These beneficial effects of Chlorella might be due to synergism between multiple nutrient and antioxidant compounds. However, information regarding the bioactive compounds in Chlorella is limited.

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Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials

Cited by 61 publications

References 50 publications

Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

Effects of Tetraselmis chuii Microalgae Supplementation on Ergospirometric, Haematological and Biochemical Parameters in Amateur Soccer Players

Potential of Chlorella as a Dietary Supplement to Promote Human Health

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