Effect of chlorhexidine and urinary catheter infection prevention in a Brazilian coronary ICU

Plantier, GM; Bosso, CE; Azevedo, BN; Correa, AC; Silva, AL; Raso, Vagner

doi:10.1186/cc14160

Cited by 2 publications

(3 citation statements)

References 2 publications

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Section: Introductionmentioning

confidence: 99%

“…Urinary catheter insertion is a common procedure in Intensive Care Units (ICUs) and can be a significant cause of infection in the hospital environment [7,8]. The use of CHG 2 of 10 in the periprocedural antisepsis of urinary catheterization has contributed to decreasing urinary tract infections associated with long-term urinary catheters among patients admitted to the coronary ICU [8]. Recommendations from guidelines to prevent and control catheter-associated urinary tract infections (CAUTIs) upon urinary catheterization include minimizing catheter use, using correct insertion practices, managing appropriately, monitoring infections, and promptly removing urinary catheters [9].…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical Incompatibility of Lubricating Gel Formulation Reduces Antibacterial Activity of Chlorhexidine Gluconate: In Vitro Study in Northern Thailand

Pattananandecha

Sirilun

Apichai

et al. 2022

IJERPH

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Chlorhexidine gluconate (CHG) is a cationic disinfectant. The positive charge of CHG molecules binds to phospholipid’s negative charge in bacterial cell walls, causing membrane disruption. The in vitro kinetic physical, chemical and biological incompatibilities of nine lubricating gels with 1% w/v CHG were investigated. Five containing anionic thickener, two containing nonionic thickener, and two containing cationic thickener were collected from hospitals in northern Thailand. All the anionic and nonionic lubricating gels significantly reduced (p < 0.05) the CHG amount after 5 min of exposure time from 12.54% to 54.99%, respectively. In contrast, the amount of CHG exposed with cationic lubricating gels was maintained. Antibacterial activity was significantly reduced to a 1.17–4.33 log10 reduction for Staphylococcus aureus ATCC25923 and a 1.07–3.52 log10 reduction for Escherichia coli ATCC25922 after 5 min exposure to all anionic and nonionic lubricating gels. In contrast, the two cationic lubricating gels maintained the antibacterial activity of the CHG solution (5.69 ± 0.14 and 5.45 ± 0.17 log10 reduction). The results suggest that anionic and nonionic thickeners in lubricating gel formulations may neutralize the positive charge and reduce the antibacterial activity of CHG, reducing its effectiveness as a disinfectant.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Incompatibility of Lubricating Gel Formulation Reduces Antibacterial Activity of Chlorhexidine Gluconate: In Vitro Study in Northern Thailand

Pattananandecha

Sirilun

Apichai

et al. 2022

IJERPH

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“…In the above study, 0.1% chlorhexidine mouthwash was used only to clean the meatal area during catheterization. Also, a study by Plantier et al (31) assessed the effect of chlorhexidine on the prevention of CAUTIs in ICUs, and the results showed that the use of chlorhexidine before catheterization significantly reduced CAUTIs. It should be noted that they used chlorhexidine only for disinfection during catheter insertion, without performing daily washing.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Perineal Care with Normal Saline and 2% Chlorhexidine Solution on the Rate of Catheter-Associated Urinary Tract Infection in Women Hospitalized in Intensive Care Units: A Quasi-Experimental Study

et al. 2020

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Background: Urinary tract infection is the most common site of infection associated with health care in the Intensive Care Unit (ICU) patients. Long-term catheterization is the most important risk factor for Urinary Tract Infections (UTIs). These infections are more common in women than in men. Colonized microorganisms in the perineal skin and around the urethra may move into the urinary system through the external surfaces of the urinary catheter to cause infection. Objectives: The present study aimed to compare the effect of perineal care with normal saline and 2% chlorhexidine solution on the rate of catheter-associated urinary tract infection (CAUTI) in women hospitalized in ICUs. Methods: A quasi-experimental study was performed on 70 female patients hospitalized in the ICU of Khatam-Al-Anbia Hospital of Zahedan in 2019. The research units meeting the inclusion criteria were selected using convenience sampling and then randomly divided into two groups of normal saline (n = 35) and chlorhexidine (n = 35). The perineal area of patients in the first group was washed with normal saline and the second group with 2% chlorhexidine solutions twice a day for seven days in both groups. To diagnose UTIs, urine samples were cultured on the first and seventh days. Data were analyzed using SPSS 21 via the independent t-test, chi-square test, and Fisher’s exact test at a significance level of less than 0.05. Results: Finally, 60 participants completed the study. The two groups did not differ significantly in terms of age, marital status, level of education, cause of hospitalization, antibiotic use, underlying diseases, fluid intake, and urinary output. At the end of the seventh day after the intervention, the incidence of UTIs was significantly lower in the chlorhexidine group (13.3%) than in the normal saline group (76.7%) (P = 0.001). Conclusions: The results showed that washing the perineal area every 12 hours with 2% chlorhexidine solution compared to normal saline reduces the incidence of CAUTIs in women hospitalized in ICUs. Therefore, perineal care with a 2% chlorhexidine solution is recommended for perineal care of female patients with urinary catheters hospitalized in ICUs.

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Effect of chlorhexidine and urinary catheter infection prevention in a Brazilian coronary ICU

Cited by 2 publications

References 2 publications

Pharmaceutical Incompatibility of Lubricating Gel Formulation Reduces Antibacterial Activity of Chlorhexidine Gluconate: In Vitro Study in Northern Thailand

Pharmaceutical Incompatibility of Lubricating Gel Formulation Reduces Antibacterial Activity of Chlorhexidine Gluconate: In Vitro Study in Northern Thailand

Comparison of the Effect of Perineal Care with Normal Saline and 2% Chlorhexidine Solution on the Rate of Catheter-Associated Urinary Tract Infection in Women Hospitalized in Intensive Care Units: A Quasi-Experimental Study

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