Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats

Abstract

CB can significantly ameliorate diabetes-induced sexual dysfunction. Polysaccharide and saponin-rich aqueous extract appears to have the most suitable effects on diabetes and its associated effects on sexual functionality.

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

“…Similarly, Thakur et al (2009) have reported a decrease in apoptosis of spermatozoa of T1 diabetic rats following 28 days administration of Chlorophytum borivilianum root extract. In addition, the activity of caspase-3 in the spermatozoa is significantly decreased compared to the diabetic untreated rats (Thakur et al, 2009). Studies using phenolic compounds have also yielded a similar trend of results.…”

“…Glibenclamide ↓# ↑ Sperm count, motility, viability and % normal morphology; ↓ oxidative stress and apoptosis in sperm (Thakur et al, 2009 (Khaki et al, 2014).…”

“…Several studies have demonstrated the beneficial effects of plantbased products on DM-induced oxidative stress in the sperm and testis of rats. Studies have shown that administration of root extract of Chlorophytum borivilianum for 28 days reduces nitric oxide, hydrogen peroxide and MDA levels in the sperm of STZinduced T1 diabetic rats (Thakur et al, 2009). Khaki et al (2009) have demonstrated that quercetin decreases MDA concentration and increases total antioxidant capacity of sperm in STZ-induced T1 diabetic rats.…”

Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats

“…12,18 Although it is reported that STZ treatment reduced plasma T levels in rats, this factor alone does not appear responsible for changes in copulatory behavior as T replacement did not reverse the adverse effects of diabetes on sexual behavior. 26 Although STZ-induced copulatory dysfunction might be due to reduced T responsiveness, copulatory dysfunction in the diabetic state is also a result of direct or indirect action of insulin and/or glucose on the adrenergic complex.…”

“…Mount and intromission latency, which was calculated as the time from the introduction of female to the occurrence of first mount and intromission, respectively. 18 Post ejaculatory interval was calculated as time from ejaculation until next intromission. Other principle parameters determined in this study were mount, intromission and ejaculatory frequencies.…”