Effect of chlorpromazine on blood glucose and plasma insulin in man

Erle, G; Basso, Monica; Federspil, Giovanni; Sicolo, Nicola; Scandellari, C.

doi:10.1007/bf00561782

Cited by 58 publications

(31 citation statements)

References 13 publications

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“…As in vitro (Cabrera et al 1988) and in vivo animal studies (Matsuda & Mori 1996;Reiss et al 1996) and some clinical studies (Beumont & Bergen 1982;Erle et al 1977;Foss et al 1995) have implied that hyperprolactinaemia impairs glucose tolerance and induces insulin resistance, we tested here the hypothesis that female rats rendered obese by sulpiride may display hyperinsulinaemia (and perhaps hyperglycaemia) as a compensatory mechanism to overcome insulin resistance. This way, the proposed hyperinsulinaemia (by its anabolic effect) might be an additional mechanism in neuroleptic-induced obesity in this animal model.…”

Section: Discussionmentioning

confidence: 99%

“…However, the causal effects of hyperprolactinaemia on insulin sensitivityhesistance have not been definitely proven, and additional research is required. Differences may also arise from using in vitro protocols such as the assessment of insulin receptor number in the adipocytes (Cabrera et al 1988) or in vivo procedures evaluating serum glucose and insulin levels (Cabrera et al 1988;Matsuda & Mori 1996;Reiss et al 1996), male (Reiss et al 1996) or female subjects (Cabrera et al 1988;Matsuda & Mori 1996), and humans (Beumont & Bergen 1982;Erle et al 1977;Foss et al 1995), mice (Matsuda & Mori 1996) or rats (Cabrera et al 1988;Reiss et al 1996). And finally, this experiment was on purpose conducted when the rats were in a very active phase of body weight gain, and this variable was not apparently considered in other experiments.…”

Section: Discussionmentioning

confidence: 99%

“…The insulin resistance and the subsequent hyperinsulinaemia, if physiologically relevant in the whole organism, might be a contributing factor to the excessive weight gain (Kissebah & Krakover 1994). Preliminary reports suggest that in fact, a trend toward glucose intolerance is detected in people under chronic antipsychotic administration (Beumont & Bergen 1982;Erle et al 1977;Foss et al 1995). however its relationship to the drug-induced weight gain has not been explored.…”

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confidence: 99%

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Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Baptista

Lacruz

Hernández

1998

Pharmacology & Toxicology

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Ahsfruct:To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals. The glucose area under the curve did not differ between the groups (P=0.24), however, the area under the insulin curve was significantly decreased by sulpiride (55.252.8 versus 115.6t 18.9, P=0.007). The results suggest that insulin resistance and hyperinsulinaemia are not involved in the excessive weight gain observed in this animal model of drug-induced obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Baptista

Lacruz

Hernández

1998

Pharmacology & Toxicology

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“…18 Alguns relatos sugerem que as fenotiazinas reduzem a secreção da insulina e aumentam a liberação de catecolaminas. 19 Estes resultados, porém, ainda não foram reproduzidos. Além disso, receptores da serotonina (5-HT 1A e 5-HT 2 ) podem estar envolvidos no controle glicêmico, reduzindo a responsividade das células beta pancreáticas aos níveis sanguíneos de glicose.…”

Section: Mecanismos Geraisunclassified

Diabetes mellitus e antipsicóticos atípicos

Sena

Sampaio

Quarantini

et al. 2003

Rev. Bras. Psiquiatr.

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IntroduçãoDe acordo com o Centro de Controle e Prevenção de Doenças, em 1997, 10,3 milhões da população total tiveram o diagnóstico de diabetes mellitus nos EUA e estima-se que cerca de outras 5,4 milhões continuem sem diagnóstico.1 O diabetes mellitus é uma afecção de grande relevância clínica por levar a danos na microvasculatura, afetando rins, retina e neurônios periféricos, assim como à aterosclerose, com elevação do risco de eventos cardíacos e cerebrovasculares. Pacientes esquizofrênicos têm maior risco para desenvolvimento de transtorno hiperglicêmico e o uso de antipsicóticos parece ampliar o risco de desenvolvimento de diabetes mellitus. O presente trabalho é uma revisão da literatura acerca da relação entre antipsicóticos atípicos e risco de desenvolvimento de diabetes mellitus. A pesquisa bibliográfica foi realizada por meio dos bancos de dados Medline e Webofscience enfocando os seguintes tópicos: "Hyperglycemia", "Diabetes Mellitus", "Antipsychotic Agents", com o objetivo de identificar artigos originais e de revisão compreendidos entre 1997 e setembro de 2002. Conclui-se pela existência de maior risco de desenvolvimento de alterações glicídicas na população de pacientes utilizando medicamentos antipsicóticos. Medidas higieno-dietéticas e atenção aos fatores de risco devem ser levados em conta no tratamento de pacientes psicóticos. Hiperglicemia. Diabetes mellitus. Agentes antipsicóticos.Schizophrenic patients present a higher risk for the development of hyperglycemic disorder and the use of antipsychotic drugs seems to increase the risk of diabetes mellitus. The present review concerns the relation between atypical antipsychotic drugs and the risk of developing diabetes mellitus. A Medline and Webofscience search was performed by using the terms "Hyperglycemia", "Diabetes Mellitus" and "Antipsychotic Agents", to identify original papers and reviews published between 1997 and september 2002. It is concluded that there is a higher risk of glycemic disorders in the population of patients treated by antipsychotic drugs. Dietetic measures and attention to risk factors should be taken into account during the treatment of psychotic patients.Hyperglycemia. Diabetes mellitus. Antipsychotic agents. Resumo Descritores AbstractKeywords dários. Dentre eles, podemos citar o ganho de peso, diabetes, hiperglicemia e dislipidemia. Tais condições levam a complicações, incluindo risco de doença cardiovascular, traduzida no aumento da morbimortalidade nestes pacientes. [4][5][6] Desta forma, psiquiatras e clínicos têm se preocupado cada vez mais em adequar a prescrição ao perfil do paciente, questionando sobre outros fatores de risco, como hipertensão, diabetes prévia, idade maior que 50 anos, raça e história familiar. Além disso, o monitoramento dos níveis glicêmicos e ponderais deve ser feito para orientar estratégias no tratamento destas alterações. 6 MétodosEste trabalho revisa os artigos publicados na literatura inter-

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“…Furthermore, Thonnard-Neumann (24) reported that the phenothiazine derivative increased the rate of patients becoming diabetic and called this phenomenon "phenothiazine diabetes". In addition, Erle et al (25) report that higher acute doses of the drug may induce hyperglycaemia and can inhibit insulin secretion both in normal individuals and in patients with latent diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

The Elucidation of the Mechanism of Weight Gain and Glucose Tolerance Abnormalities Induced by Chlorpromazine

et al. 2006

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Abstract. Antipsychotic drugs induce weight gain and metabolic abnormalities. Recently, the role of adipocytokines secreted from adipocytes in the development of metabolic syndrome has received attention. The aim of this study was to investigate the effects of chlorpromazine (Cp) on body weight, glucose, lipid metabolism, and adipocytokine secretion in rats fed sucrose. Wistar rats received 15% sucrose (Suc group), 15% sucrose and Cp at 7.5 mg / kg per day (Suc + Cp group), or Cp alone (Cp group) in water for 10 weeks. Fasting glucose levels in the Suc and Suc + Cp groups were significantly higher than in the control (Cont) group. Fasting insulin levels in the Suc, Suc + Cp, and Cp groups were also significantly higher than in the Cont group. The adiponectin level in the Suc group was significantly higher than in the Cont group, although the adiponectin level in the Suc + Cp group was not. Furthermore, the plasma tumor necrosis factor (TNF)-α level in the Suc + Cp group was significantly higher than in the Suc group. These data suggest that Cp inhibits the compensatory response of adiponectin with respect to obesity due to increased expression of plasma TNF-α level. Cp may exert more harmful effects on the glucose level and insulin resistance than on other factors, which may be one of the mechanisms responsible for the metabolic syndrome induced by antipsychotic agents.

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Effect of chlorpromazine on blood glucose and plasma insulin in man

Cited by 58 publications

References 13 publications

Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Diabetes mellitus e antipsicóticos atípicos

The Elucidation of the Mechanism of Weight Gain and Glucose Tolerance Abnormalities Induced by Chlorpromazine

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