Effect of Cholecystectomy on Lipid Profile in Bangladeshi Patients with Cholelithiasis

Abstract

Objective: As no studies were reported from Bangladesh, the present study was conducted on serum lipid profile, i.e. triglyceride TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoproteincholesterol (HDL-C) in Bangladeshi patients with cholelithiasis Patients and methods: A total of 44 adult patients with cholelithiasis and 30 healthy subjects as normal controls (NC) were included in the study. The blood samples were taken from fasting patients at diagnosis before cholecystectomy (Serum-I 0 ), gall bladder bile during cholecystectomy (Bile-I 0 ) and blood sample again after 2-3 months at follow-up (Serum-II 0 ) and from fasting NC subjects. TG, TC, LDL-C and HDL-C were quantitated in serum and bile by standard methods using research kits from reputed companies. The results were compared statistically by ANOVA and Student's t-test using SPSS propramme Results: TG level was elevated in Serum-I 0 , Bile-I 0 and Serum-II 0 of patients, being highest in Bile-I 0 compared to controls (NC) (p<0.001). TG level was reduced in serum -II 0 after cholecystectomy compared to Serum-I 0 and Bile-I 0 , although it remained significantly elevated compared to controls (NC) (p<0.001). TC level was elevated in Bile-I 0 compared to Serum-I 0 and Serum-II 0 (p<0.001). Interestingly, TC was elevated in Serum-II 0 after cholecystectomy, although no significant difference was observed between NC and patients Serum-I 0 (p=0.835). LDL-C levels in NC, Serum-I 0 and Serum-II 0 were similar (p=0.126, p=0.121), although Serum-II 0 levels was elevated compared to Serum-I 0 (p<0.001) and it was much elevated in Bile-I 0 (p<0.001). HDL-C levels were similar (p>0.05) among NC, Serum-I 0 and Serum-II 0 , but it was higher in Bile-I 0 significantly (p<0.001) Conclusion:Alterations in lipid profile in cholelithiasis were significant but complex and cholecystectomy had profound impact suggesting a crucial role of gall bladder. The results were discussed accordingly.

The effect of cholecystectomy on the lipid profile of patients with gallstone disease: a prospective study

“…These results were similar to those of other studies. [15][16][17][18]20,22 Nature of gallstone and lipid profile: In our study, the majority of the subjects had cholesterol stones (51%), followed by mixed stones (43%). Only a few patients (6 %) had pigmented stones.…”

“…Hypertriglyceridemia, hypercholesterolemia, and low level of HDL-cholesterol were the abnormalities documented which were as those in similar studies in the past. 18,19 The effect of cholecystectomy on lipid profile: Theoretically, cholecystectomy would result in a favourable alteration in the lipid profile. These changes in the lipid values are partly due to enhanced secretion of phospholipids and bile acids into bile following cholecystectomy.…”

“…Recent studies have shown that there is an improvement in the lipid profile following cholecystectomy. [15][16][17][18][19][20] The hypothesis is that postcholecystectomy there is a reduction in the bile acid pool size and an increase in the frequency of entero-hepatic circulation. This causes a decrease in total cholesterol and low density lipoprotein (LDL)-cholesterol levels.…”

Lipoprotein (a) Status and Effect of Laparoscopic Cholecystectomy on it in Bangladeshi Patients with Cholelithiasis

“…Previously, we reported the results on lipid profile i.e. triglyceride (TG), total cholesterol (TC), low density lipoproteincholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels in serum and bile of cholelithiasis patients before cholecystectomy (I 0 ) and after cholecystectomy (II 0 ) and in normal control subjects [27]. In the present article, we have reported results of the study on Lp(a) status in serum and bile of cholelithiasis patients preoperatively and postoperatively at MRU, MHWT Dhaka, Bangladesh.…”

“…In the present article, we have reported results of the study on Lp(a) status in serum and bile of cholelithiasis patients preoperatively and postoperatively at MRU, MHWT Dhaka, Bangladesh. The patients with gallstone disease (cholelithiasis) were diagnosed as having cholelithiasis according to standard clinical and laboratory criteria as practiced in hospital and patients not fulfilling the criteria for our study on cholelithiasis were excluded [27][28][29]. The diagnostic algorithm for cholelithiasis were taking medical history, clinical examination, ultrasonogram (USG) of hepato-biliary system and pancreas and routine laboratory investigations including liver function tests (LFTs).…”