Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski, K.

doi:10.2754/avb200776010017

Cited by 6 publications

(7 citation statements)

References 40 publications

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“…The MR was observed in sheep, in the several own studies (Romański, 2002;2007;2009b;2010) and in the studies on sheep and calf reported by others (Fleckenstein et al, 1982;Poncet & Ivan, 1984;Ruckebusch, 1989). Therefore, the MR represents the well-established motility pattern.…”

Section: Discussionmentioning

confidence: 76%

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The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

Romanski¹

2016

BJVM

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SummaryRomański, K. W., 2016. The 'minute rhythm' incidence in the ovine abomasal antrum and small intestine. Bulg. J. Vet. Med., 19, No 3,[200][201][202][203][204][205][206][207][208] To characterise further the 'minute rhythm', six healthy rams were equipped with serosal electrodes sewn onto the abomasal antrum and the small bowel. The experiments were performed before and after feeding. Food was offered during phase 2a or 2b of the migrating motility complex. The 'minute rhythm' incidence and coordination were assessed during four 5-minute observation periods. In the duodenal bulb and duodenum, the pattern was observed more frequently than in other segments examined. During phase 2b, the 'minute rhythm' incidence was often more frequent than during phase 2a of the migrating motility complex. Feeding increased significantly the 'minute rhythm' incidence, but these alterations were more evident during first two observation periods. In the jejunum, duration of one 'minute rhythm' episode was longer than in more proximal segments. In the more distal jejunal recording site the 'minute rhythm' was often absent. The pattern was well coordinated mostly in the antroduodenum and its propagation velocity was the highest also in the upper small bowel. It is concluded that the 'minute rhythm' incidence, form, and coordination depended upon the feeding conditions, intensity of intestinal motility and the gastrointestinal segment.

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Section: Discussionmentioning

confidence: 76%

“…Such variability has resulted clearly also from the other studies and it was dependent on the animal species, site of occurrence (i.e. the gastrointestinal segment), and feeding conditions (Fleckenstein et al, 1982;Romański, 2002;2007).…”

Section: Discussionmentioning

confidence: 97%

The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

Romanski¹

2016

BJVM

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“…This problem was briefly discussed earlier (Romański, 2004) and it was clear that this question should be dealt with separately for each gastrointestinal region. The essential corollaries emerging from the previous study concerning the ovine duodenum pointed out that the equipotent doses of cerulein and CCK-OP oscillate between 1:8 and 1:15 (Romański, 2007b). This remains in concert only with that part of the present study where CCK-OP, administered at a 20 times higher dose than cerulein, exerted a stronger effect and comprised the inhibition of myoelectric activity in the duodenal bulb and the duodenum, but not stimulatory changes, although the differences were not consistent.…”

Section: Discussionmentioning

confidence: 99%

“…However, the opposite and dual effects of CCK-OP and its amphibian analogue, cerulein, have been reported (Giuliani et al, 1990;Martins et al, 2006). In sheep, CCK peptides also inhibit the arrival of the MMC in the upper small intestine, but their effect on intestinal motility has not been fully elucidated so far in spite of several studies performed (Bueno and Praddaude, 1979;Cottrell and Iggo, 1984;Ormas et al, 1984;Onaga et al, 1997;Romański, 2004Romański, , 2007b. Thus the dual effect of CCK upon the small-intestinal motility can also be expected in sheep.…”

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confidence: 97%

Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep

Romanski¹

2010

CZECH J ANIM SCI

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Cholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP) and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of chronic experiments. Five rams underwent the implantation of a strain gauge force transducer to the duodenal wall, and -additionally -the bipolar platinum electrodes to the duodenal bulb, distal duodenum, near the strain gauge force transducer, and proximal jejunum. During continuous motor recordings, 0.15M NaCl or CCK peptides were administrated intravenously. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2 000 (over 30, 60, or 120 s) ng/kg of body weight and injections of cerulein at doses of 1, 10, or 100 ng/kg (given over the same periods) were each administered in the course of duodenal phase 1, 2a, or 2b of the migrating motor complex (MMC), i.e. 5 min after the onset of each phase. Injections of the smallest doses of CCK peptides exerted a slight and mostly insignificant effect on the duodenal areas under contraction (AUC). In the duodenum, the moderate doses of the hormones evoked short stimulatory effects followed by longer inhibitory biphasic effects on AUC. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes stimulatory and inhibitory (biphasic) physiological effects on duodenal motility in sheep.

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“…However, opposite and dual effects of CCK-OP and cerulein have also been reported (Giuliani et al, 1990). In sheep, CCK affects the small-intestinal myoelectric and motor activity and also inhibits the arrival of the MMC in the upper small intestine, but despite several studies, its effect on intestinal motility has not been fully elucidated so far (Bueno and Praddaude, 1979;Romański, 2004Romański, , 2007aRomański, , 2007b. CCK is usually applied as CCK-octapeptide (CCK-OP), the natural CCK form present in sheep (Titchen, 1986) and it was applied here.…”

mentioning

confidence: 99%

Dose-related effects of cholecystokinin octapeptide administered during various phases of the migrating motor complex on small-intestinal motility in sheep

Romanski

2009

Acta Veterinaria Hungarica

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Cholecystokinin (CCK) may affect intestinal motility, but in ruminants its precise effects have not been entirely explored. The aim of this study was to examine the effects of CCK-octapeptide (CCK-OP) on small-intestinal myoelectric activity in rams in the course of chronic experiments. Five rams underwent implantation of bipolar platinum electrodes to the duodenal bulb, distal duodenum, and jejunum as well as a strain gauge force transducer attached near the duodenal electrode. During continuous myoelectric recordings, 0.15 M NaCl or CCK-OP were injected slowly into the jugular vein. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s) and 2000 (over 30, 60 or 120 s) ng/kg of body weight were each administered 5 or 30-40 min after the onset of the duodenal phase 1 or phase 2 of the migrating myoelectric complex (MMC), respectively. Most of these CCK doses were considered physiological. Injections of the smallest dose of CCK-OP exerted a slight and mostly insignificant inhibitory effect on the duodenal bulb and the duodenal myoelectric activity index (MAI) values. In the duodenal bulb, the effects of CCK-OP on myoelectric activity were dose dependent and closely related to the phase of the MMC. In the duodenum, the high dose of the hormone evoked short stimulatory and longer inhibitory biphasic effects on the MAI. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes a physiological stimulatory and inhibitory (biphasic) effect on the duodenal bulb and duodenal motility in sheep, with the inhibitory effect of the hormone being more pronounced in the duodenal bulb than in the duodenum. These effects were related to the CCK dose and the MMC phase. Therefore, CCK is an important regulator of upper small bowel motility in sheep.

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Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Cited by 6 publications

References 40 publications

The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep

Dose-related effects of cholecystokinin octapeptide administered during various phases of the migrating motor complex on small-intestinal motility in sheep

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