Effect of chronic administration of sildenafil citrate (Viagra) on the histology of the retina and optic nerve of adult male rat

Eltony, Sohair A.; Abdelhameed, Sally Y.

doi:10.1016/j.tice.2017.01.006

Cited by 17 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The light and electron microscopic findings of the present study clearly revealed that the oral administration of tadalafil for six weeks has altered the structure of retina leading to disorganized retinal layers in addition to evident degenerative changes such as detached retinal pigmented epithelium, cytoplasmic vacuolations and nuclear pyknosis of some photoreceptors as well as many cells of inner nuclear layer and ganglion cell layer. Similar results were recorded by some authors [36] who studied the effect of another PDE-5 inhibitor; sildenafil citrate on the rat retina. Moreover, other physiological studies stated that PDE-5 enzyme inhibitors decrease retinal ganglion cells light response and reversibly inhibit the photo-transduction in retina of monkeys [37,38] .…”

Section: Discussionsupporting

confidence: 88%

Kiwifruit extract attenuates tadalafil induced retinal injury in adult male albino rats: a histological and immunohistochemical study

Kassab

Elwan

2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

Background: Tadalafil is a one of the commonly prescribed drugs for treatment of erectile dysfunction. Several ocular side effects have been reported with tadalafil therapy. Kiwi fruit is a popular fruit that has a wide range of pharmacological activities and a proposed role in combating serious ocular complications. Aim: To evaluate the potential protective role of kiwi fruit extract (KFE) against tadalafil induced retinal injury in adult male albino rats. Material and Methods: Thirty adult male albino rats were divided into four groups; control group, KFE-treated group (500 mg/kg), Tadalafil-treated group (1.8 mg/kg), and both Tadalafil & KFE-treated group. Animals were orally administered once daily for six weeks. Specimens from the retina were processed for light and electron microscopy. Immunohistochemical study was performed using antibodies against B-cell lymphoma 2 (Bcl-2). Results: Specimens from tadalafil-treated animals showed a statistically significant decrease in the total retinal thickness and the ganglion cell number. The retinal pigmented epithelium was detached. The inner segment of the photoreceptor was irregularly oriented with interrupted outer limiting membrane. Dark pyknotic nuclei were observed in the outer and inner nuclear layers and the ganglion cell layer. Ultrastructurally, disorganized membranous discs with increased inter-disc spaces of the outer segment, cytoplasmic vacuoles and swollen mitochondria of the inner segment of the photoreceptor layer and shrunken irregular cell bodies and nuclei of the outer and inner nuclear and ganglion cell layers were observed. The immunohistochemical study showed a significant decrease in Bcl-2 immunoreaction. In contrast, minimal changes were observed in rats treated concomitantly with both tadalafil and kiwi fruit extract, with a non-significant decrease in the immunoreaction. Conclusion: Tadalafil induced structural changes in the retina of adult albino rat that could be ameliorated by concomitant treatment with kiwi fruit extract.

show abstract

Section: Discussionsupporting

confidence: 88%

Kiwifruit extract attenuates tadalafil induced retinal injury in adult male albino rats: a histological and immunohistochemical study

Kassab

Elwan

2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

show abstract

“…The most experimental studies with sildenafil described a venous dilatation and an increased flow, contrary to the study of Grunwald et al, which reported no effect on retinal circulation [4 -6]. Eltony et al postulated a toxic effect of chronic treatment with sildenafil in adult male rats, whereas Moschos reported no permanent toxic effects on chorioretinal tissue in humans after sildenafil intake [7,8]. Ophthalmic adverse drug re- A preretinal hemorrhage is usually induced by Valsalva retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Striking Funduscopic Findings in a Patient after Drug-Supported Sexual Activity

Steinemann

Waizel

Sagri³

et al. 2020

Klin Monatsbl Augenheilkd

View full text Add to dashboard Cite

“…The mechanism of action of Tadalafil in treatment of ED is related to cyclic guanosine monophosphate (cGMP). [7] During sexual activity, nitric oxide (NO) released from cavernous nerves. This NO stimulates guanylate cyclase enzyme formed cGMP.…”

Section: Discussionmentioning

confidence: 99%

“…cGMP relaxes smooth muscle vessel that increased blood flow into corpus cavernosum and subsequent penile erection is happen. [17]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anterior ischemic optic neuropathy in a patient with erectile dysfunction: Tadalafil as an offending medication

et al. 2018

View full text Add to dashboard Cite

Erectile dysfunction (ED) has negative effects on quality of life. The first line of oral medication for this condition is phosphodiesterase type 5 inhibitors (PDE5I) including Tadalafil. Ocular complications associated with Tadalafil are rare and usually occurred in participant with known risk factors. In this report, we describe and review the related literature of development of nonarteritic anterior ischemic optic neuropathy -associated Tadalafil. A healthy nonsmoking 42-year-old male with a history of ED presented with acute onset of an inferior visual field defect on the right eye. Automated perimetry showed inferior altitudinal loss in the affected eye. The administration of Tadalafil was discontinued as a potential causative agent for this condition. During follow-up, neither improvement signs nor symptoms revealed.

show abstract

Effect of chronic administration of sildenafil citrate (Viagra) on the histology of the retina and optic nerve of adult male rat

Cited by 17 publications

References 37 publications

Kiwifruit extract attenuates tadalafil induced retinal injury in adult male albino rats: a histological and immunohistochemical study

Kiwifruit extract attenuates tadalafil induced retinal injury in adult male albino rats: a histological and immunohistochemical study

Striking Funduscopic Findings in a Patient after Drug-Supported Sexual Activity

Anterior ischemic optic neuropathy in a patient with erectile dysfunction: Tadalafil as an offending medication

Contact Info

Product

Resources

About