Effect of Chronic Administration of Aminoguanidine on Vascular Reactivity of the Greater Circulation in Rats with Monocrotaline-induced Pulmonary Hypertension

Бонарцев, А. П.; Kb, D'iakonov; Ab, Postnikov; Na, Medvedeva

doi:10.1007/s10525-005-0099-x

Cited by 1 publication

(1 citation statement)

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“…Treatment of wild-type mice with the iNOS inhibitor N (6)- (1-iminoethyl)-L-lysine (L-NIL) prevents structural and functional alterations in the lung vasculature and alveoli and reverses emphysema and PH ( 127 ). In hypoxia-induced PH, iNOS may release large amounts of NO and damage the vascular endothelium, and the endothelial damage will diminish NO bioavailability ( 75 , 128 , 129 ). MDSCs can promote immune suppression by the production of ROS ( 40 ).…”

Section: Introductionmentioning

confidence: 99%

Myeloid-derived suppressor cells and pulmonary hypertension

Zhang,

Li,

et al. 2023

Front. Immunol.

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Pulmonary hypertension (PH) is a chronic pulmonary vascular disorder characterized by an increase in pulmonary vascular resistance and pulmonary arterial pressure. The detailed molecular mechanisms remain unclear. In recent decades, increasing evidence shows that altered immune microenvironment, comprised of immune cells, mesenchymal cells, extra-cellular matrix and signaling molecules, might induce the development of PH. Myeloid-derived suppressor cells (MDSCs) have been proposed over 30 years, and the functional importance of MDSCs in the immune system is appreciated recently. MDSCs are a heterogeneous group of cells that expand during cancer, chronic inflammation and infection, which have a remarkable ability to suppress T-cell responses and may exacerbate the development of diseases. Thus, targeting MDSCs has become a novel strategy to overcome immune evasion, especially in tumor immunotherapy. Nowadays, severe PH is accepted as a cancer-like disease, and MDSCs are closely related to the development and prognosis of PH. Here, we review the relationship between MDSCs and PH with respect to immune cells, cytokines, chemokines and metabolism, hoping that the key therapeutic targets of MDSCs can be identified in the treatment of PH, especially in severe PH.

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