Effect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices

Russell, Vivienne A.; Nurse, Barbara; Lamma, Manja Constance Louise; Taljaard, J. J. F.

doi:10.1016/s0006-8993(87)80023-9

Cited by 9 publications

(2 citation statements)

References 33 publications

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“…This is in agreement with certain authors (12)(13)(14) who have similarly reported no effect, while others (15,17) have observed decreases with ethanol in striatal preparations. Furthermore, the o~2-adrenoceptor-mediated (27) inhibition of the K+-stimulated release of [3H]DA from nucleus accumbens slices was unaffected by prior addition of ethanol to the superfusion buffer. The mechanism involved in a2-adrenoceptor-mediated modulation of [3H]DA release from nucleus accumbens slices was therefore not affected by exposure of the tissue to ethanol.…”

Section: Discussionmentioning

confidence: 91%

Effect of ethanol on [3H]Dopamine release in rat nucleus accumbens and striatal slices

1988

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Ethanol (10-200 mM) transiently increased tritium overflow from superfused rat nucleus accumbens slices previously incubated with [3H]dopamine (DA) and [14C]choline. The effect was greater in striatal tissue and did not appear to be a non-specific membrane effect since [14C]acetylcholine (ACh) release was not affected. Lack of antagonism by picrotoxin suggested that gamma-aminobutyric acid (GABA) receptors were not involved. Calcium was not a requirement and the DA uptake blocker, nomifensine, was without effect. Ethanol appeared to be causing [3H]DA release into the cytoplasm. K+ -stimulated release of [3H]DA and [14C]ACh from nucleus accumbens and striatal slices was not affected. Clonidine-mediated inhibition of the K+-evoked release of [3H]DA remained unaltered. Ethanol attenuated the isoproterenol-induced enhancement of [3H]DA release. Ethanol therefore appeared to interact with components of the DA terminal causing a transient increase in the release of neurotransmitter without impairing K+-evoked release but apparently interfering with the isoproterenol-induced effect.

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Section: Discussionmentioning

confidence: 91%

Effect of ethanol on [3H]Dopamine release in rat nucleus accumbens and striatal slices

1988

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“…[2,5,6-3H]Dopamine (6-15 Ci/mmol) was obtained from Amersham Int; benztropine methanesulfonate, 5-hydroxytryptamine creatinine sulfate, 3-hydroxytyramine. HC1, 5-methoxytryptamine.…”

Section: Methodsmentioning

confidence: 99%

Characterization of the effects of serotonin on the release of [3H]dopamine from rat nucleus accumbens and striatal slices

1988

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The effect of serotonin agonists on the depolarization (K+)-induced, calcium-dependent, release of [3H]dopamine (DA) from rat nucleus accumbens and striatal slices was investigated. Serotonin enhanced basal 3H overflow and reduced K+-induced release of [3H]DA from nucleus accumbens slices. The effect of serotonin on basal 3H overflow was not altered by the serotonin antagonist, methysergide, or the serotonin re-uptake blocker, chlorimipramine, but was reversed by the DA re-uptake carrier inhibitors nomifensine and benztropine. With the effect on basal overflow blocked, serotonin did not modulate K+-induced release of [3H]DA in the nucleus accumbens or striatum. The serotonin agonists, quipazine (in the presence of nomifensine) and 5-methoxytryptamine, did not significantly affect K+-induced release of [3H]DA in the nucleus accumbens. This study does not support suggestions that serotonin receptors inhibit the depolarization-induced release of dopamine in the nucleus accumbens or striatum of the rat brain. The present results do not preclude the possibility that serotonin may affect the mesolimbic reward system at a site which is post-synaptic to dopaminergic terminals in the nucleus accumbens.

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Presynaptic ?2A-adrenoceptors inhibit the release of endogenous dopamine in rabbit caudate nucleus slices

Trendelenburg

Starke

Limberger

1994

Naunyn-Schmiedeberg's Arch Pharmacol

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alpha 2-Adrenoceptors modulating the release of dopamine were identified and characterized in slices of the head of the rabbit caudate nucleus. Release of endogenous dopamine was measured by fast cyclic voltammetry as the increase in the extracellular concentration of dopamine elicited by electrical stimulation. The electrochemical signal was identified as dopamine by means of the oxidation potential, the voltammogram and the fact that the signal was not changed by desipramine, which inhibits the high affinity uptake of noradrenaline, but was greatly increased by nomifensine, which in addition inhibits the high affinity uptake of dopamine. Stimulation by 6 pulses/100 Hz increased the extracellular concentration of dopamine by about 85 nM. The selective alpha 2-adrenoceptor agonist 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14,304) reduced this release with an EC50 of 173 nM and by maximally 75%. The alpha 2-adrenoceptor agonists clonidine and oxymetazoline only tended to cause a decrease. Six drugs, including oxymetazoline, were tested as antagonists against UK 14,304. Their order of antagonist potency (pKD values in brackets) was rauwolscine (8.0) > oxymetazoline (7.5) > 2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane (WB 4101; 7.3) > phentolamine (7.1) > corynanthine (5.1) approximately prazosin (<6). Given alone, the antagonists did not change the release of dopamine elicited by 6 pulses/100 Hz, and the same was true for the dopamine receptor antagonist sulpiride. When caudate slices were stimulated by 10 pulses/1 Hz, sulpiride increased the release of dopamine. Desipramine and rauwolscine, in contrast, again caused no change. It is concluded that dopaminergic axons in the rabbit caudate nucleus possess release-inhibiting alpha 2-adrenoceptors.2+ off

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Effect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices

Cited by 9 publications

References 33 publications

Effect of ethanol on [3H]Dopamine release in rat nucleus accumbens and striatal slices

Effect of ethanol on [3H]Dopamine release in rat nucleus accumbens and striatal slices

Characterization of the effects of serotonin on the release of [3H]dopamine from rat nucleus accumbens and striatal slices

Presynaptic ?2A-adrenoceptors inhibit the release of endogenous dopamine in rabbit caudate nucleus slices

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