Effect of Chronic Consumption of IBIE Leave (mucuna 1 flagellipes) on Locomotor behaviour in CD-1 Mice

Abstract

The aim of the study is to investigate the effect of chronic consumption of Ibie leave (Mucuna flagellipes) on locomotor behaviour and thus discover the potential of this underutilized plant in managing locomotor disorders. The open field was used to study locomotor behaviours in 25 Swiss white mice weighing 18g-22g.The mice were grouped into two groups consisting of 9 mice each. Group 1 which served as the control group received normal rat chow (20g) and clean drinking water; while Group 2, which serve as the test group received (20gw/w) Ibie leave diet. Each mouse was tested in the open field arena for 5 minutes and behaviours scored. ANOVA and post-hoc t-test were employed for statistical analysis and P<0.05, were accepted as significant. The results showed that the frequency of line crosses and rearing were statistically lower (P< 0.01) in the Mucuna flagellipes diet group compared to the control. Therefore, chronic consumption of Ibie (Mucuna flagellipes) diet reduces locomotor behaviour in mice.