Effect of Chronic Dietary Treatment with Z-Tryptophan on the Development of Cold-Induced Hypertension in Rats

Riesselmann, Anne; Baron, Andrew W.; Fregly, Melvin J.; Cade, J. R.

doi:10.1159/000138818

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…According to Lark et al [10] and Riesselmann et al [11], tryptophan prevented its development; Wolf et al [12] demonstrated that the effects of tryptophan on hypertension depended on its dose. The influence of tryptophan on pregnancy-induced hypertension is still unexplained.…”

Section: Wwwahviamedicaplmentioning

confidence: 99%

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Plasma concentration of tryptophan and pregnancy-induced hypertension

Grafka

Łopucki

Karwasik-Kajszczarek

et al. 2018

Arterial Hypertension

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Introduction. Pregnancy-induced hypertension (PIH) is one of the main clinical problems of unexplained etiopathogenesis. New factors involved in the pathogenesis of this disease are still being searched. The available literature lacks data regarding the differences in tryptophan concentrations in physiological and PIH-complicated pregnancy. Previous studies have shown that L-tryptophan treatment reduces blood pressure in hypertensive rats. The direct vascular effects of tryptophan have not been fully explored. In this study, the stimulating effect of tryptophan on the development of PIH was revealed. The aim of the present study was to assess the differences in plasma tryptophan concentrations in physiological pregnancies and pregnancies complicated with hypertension in the third trimester. Material and methods. The study was carried on 105 complicated by PIH and 105 pregnant women with blood pressure within normal limits between 25 and 41 weeks of gestation. Tryptophan concentration was determined by the automated ion-exchange chromatography using an Amino Acid Analyser (AAA 400) by Ingos, Czech Republic. Tryptophan concentration was expressed in μmol/cm 3 plasma. Results. The mean concentration of tryptophan in the third trimester of physiological pregnancy was found to be 0.035 ± 0.009 μmol/cm

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Section: Wwwahviamedicaplmentioning

confidence: 99%

“…Riesselmann et al [11] evaluated effects of tryptophan therapeutic diet on the development of cold-induced hypertension in rats. Continuous administration of lower doses of L-tryptophan (850 mg/ /day) prevented an increase in blood pressure, reduced hypertrophy of the heart and did not affect the body weight during exposure to cold.…”

Section: Wwwahviamedicaplmentioning

confidence: 99%

Plasma concentration of tryptophan and pregnancy-induced hypertension

Grafka

Łopucki

Karwasik-Kajszczarek

et al. 2018

Arterial Hypertension

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“…Previous studies from this laboratory have shown a linear decline in the elevated urinary output, and presumably plasma concentra tion, of norepinephrine during chronic expo sure to cold [ 10,23,26]. Since PRA is directly related to urinary output of norepinephrine in the cold-exposed rat [10], the decline of the latter during exposure to cold should be ac companied by a decline in PRA.…”

Section: Discussionmentioning

confidence: 82%

Effect of Chronic Exposure to Cold on Vascular Responsiveness to Phenylephrine and Angiotensin II

Fregly

Brummermann²

1993

Pharmacology

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Chronic exposure of rats to cold (5°C, 3-4 weeks) results in the development of hypertension. To assess potential mechanisms by which this may occur, the vascular responsiveness to administration of phenylephrine (an α-adrenergic agonist) and angiotensin II (AII) was studied in unanesthetized rats at 1, 3 and 5 weeks of exposure to cold (5°C). Vascular responsiveness to intravenous administration of graded doses of phenylephrine was reduced in cold-treated rats, the earliest effect being observed within 1 week of exposure. With respect to AII, vascular responsiveness to graded intravenous doses increased maximally within 1 week of exposure to cold and returned toward the level of the control group at 3 weeks. After 5 weeks of exposure to cold, it had returned to the level of the control group. These results suggest that vascular responsiveness to α-adrenergic stimulation appears to be directed toward prevention of an elevation of blood pressure in cold-treated rats. In contrast, vascular responsiveness to administration of AII is increased during the first 3 weeks of exposure to cold, at a time when plasma renin activity is also increased, and may thus play an important role in the initiation of cold-induced elevation of blood pressure.

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“…The significant interac tion of these two compounds in attenuating the elevation of blood pressure, mentioned above, suggests that the mechanisms involved are different, such that the combination of the two drugs results in greater responses than would be expected from the summation of the two individual responses. Additional studies from this and other lab oratories have shown that chronic treatment with tryptophan protects against the develop ment of DOCA-induced, Dahl salt-sensitive, spontaneously induced, renal-induced, and cold-induced hypertensions in rats [1][2][3][4][9][10][11][12][13]. In addition, chronic administration of tryptophan to humans with borderline essen tial hypertension has been shown to reduce blood pressure [14,15].…”

Section: Discussionmentioning

confidence: 85%

Effect of Pyridoxine and Tryptophan, Alone and Combined, on the Development of Deoxycorticosterone Acetate-Induced Hypertension in Rats

Fregly

Cade²

1995

Pharmacology

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Chronic dietary administration of pyridoxine HC1 (300 mg/kg/day), L-tryptophan (1.26 g/kg/day), or a combination of the two can attenuate the elevation of systolic blood pressure in DOCA-salt-treated rats. With these treatments, the characteristic increase in the weight of the heart accompanying chronic administration of DOCA (786 µg/kg/day) was also attenuated. Thus, both tryptophan and pyridoxine possess antihypertensive properties, and the combination of the two appeared to provide greater protection than either alone. The results are consistent with the possibility that pyridoxine, an important cofactor in the metabolic pathways for tryptophan, may facilitate the conversion of tryptophan to antihypertensive compounds. Additional studies will be required to determine which of the metabolites of tryptophan possess antihypertensive properties. Pyridoxal phosphate, one of the metabolites of pyridoxine, was also administered chronically in the diet (1.0 and 2.0% by weight) to rats whose blood pressures were elevated by administration of DOCA. The results of this study suggest that pyridoxal phosphate can also lower the blood pressure of rats with established hypertension. Thus, these studies reveal that pyridoxine, pyridoxal phosphate and tryptophan are potential antihypertensive agents.

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Effect of Chronic Dietary Treatment with Z-Tryptophan on the Development of Cold-Induced Hypertension in Rats

Cited by 6 publications

References 30 publications

Plasma concentration of tryptophan and pregnancy-induced hypertension

Plasma concentration of tryptophan and pregnancy-induced hypertension

Effect of Chronic Exposure to Cold on Vascular Responsiveness to Phenylephrine and Angiotensin II

Effect of Pyridoxine and Tryptophan, Alone and Combined, on the Development of Deoxycorticosterone Acetate-Induced Hypertension in Rats

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