Effect of Chronic Ethanol Exposure on Female Rat Reproductive Cyclicity and Hormone Secretion

Emanuele, Nicholas V.; LaPaglia, Nancy; Steiner, J.; Kirsteins, L.; Emanuele, Mary Ann

doi:10.1111/j.1530-0277.2001.tb02312.x

Cited by 49 publications

(17 citation statements)

References 22 publications

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“…Specifically, earlier female pubertal development as compared to males may place females at a more neuromaturationally vulnerable stage (e.g., prefrontal synaptic pruning) at the time binge drinking begins. Hormonal level variability and menstrual cycle phase has been shown to differentially affect performance on spatially related tasks by gender (Hampson, 1995;Williams and Meck, 1991), and alcohol-induced fluctuations in hormone levels could explain the dissimilar effects of alcohol on brain activation between genders (Emanuele et al, 2001;Kim et al, 2003). Female's slower rates of gastric metabolism, higher ratio of body fat, and lower body weight may contribute to the observed differences in how alcohol affects physiology (Frezza et al, 1990;Wechsler et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Adolescent Binge Drinking Linked to Abnormal Spatial Working Memory Brain Activation: Differential Gender Effects

Squeglia

Schweinsburg

Pulido

et al. 2011

Alcoholism: Clinical and Experimental Research

214

174

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Background Binge drinking is prevalent during adolescence, and its effect on neurocognitive development is of concern. In adult and adolescent populations, heavy substance use has been associated with decrements in cognitive functioning, particularly on tasks of spatial working memory (SWM). Characterizing the gender-specific influences of heavy episodic drinking on SWM may help elucidate the early functional consequences of drinking on adolescent brain functioning. Methods 40 binge drinkers (13 females, 27 males) and 55 controls (24 females, 31 males) ages 16 to 19, completed neuropsychological testing, substance use interviews, and a spatial working memory task (SWM) during functional magnetic resonance imaging (fMRI). Results Significant binge drinking status x gender interactions were found (p<.05) in 8 brain regions spanning bilateral frontal, anterior cingulate, temporal, and cerebellar cortices. In all regions, female binge drinkers showed less SWM activation than female controls, while male bingers exhibited greater SWM response than male controls. For female binge drinkers, less activation was associated with poorer sustained attention and working memory performances (ps<.025). For male binge drinkers, greater activation was linked to better spatial performance (p<.025). Conclusion Binge drinking during adolescence is associated with gender-specific differences in frontal, temporal, and cerebellar brain activation during a SWM task, which in turn relate to cognitive performance. Activation correlates with neuropsychological performance, strengthening the argument that BOLD activation is both affected by alcohol use and is an important indicator of behavioral functioning. Females may be more vulnerable to the neurotoxic effects of heavy alcohol use during adolescence, while males may be more resilient to the deleterious effects of binge drinking. Future longitudinal research will examine the significance of SWM brain activation as an early neurocognitive marker of alcohol impact to the brain on future behaviors such as driving safety, academic performance, and neuropsychological performance.

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Section: Discussionmentioning

confidence: 99%

Adolescent Binge Drinking Linked to Abnormal Spatial Working Memory Brain Activation: Differential Gender Effects

Squeglia

Schweinsburg

Pulido

et al. 2011

Alcoholism: Clinical and Experimental Research

214

174

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“…Alcohol exposure alters estrous cyclicity in female rats (Krueger et al, 1983;Alfonso et al, 1993;Emanuele et al, 2001a). Long-term alcohol exposure in prepubertal rats produces delayed vaginal opening, altered hormone levels, absent estrous cycles, decreased ovarian and uterine weights, and immaturity in ovarian and uterine structure (Van Thiel et al, 1978;Bo et al, 1982).…”

Section: Introductionmentioning

confidence: 96%

Long‐term alcohol exposure prior to conception results in lower fetal body weights

Livy

Maier

West

2004

Birth Defects Research Pt B

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“…Mohamed et al [107] demonstrated that females with intact ovaries showed an increase in bradycardic response to phenylephrine compared to ovariectomized females. It was reported that alcohol intake increases estradiol levels in humans and in rodents [108,109], which might explain the predominance of vagal tone in females exposed to alcohol vapor, and consequently, constitute a prominent adaptative mechanism in females that preclude the occurrence of changes in cardiovascular reactivity during stressful situations.…”

Section: Discussionmentioning

confidence: 99%

Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats

de-Souza

Costa-Ferreira

et al. 2021

Preprint

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Background: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. Methods: We exposed male and female Long-Evans rats to ethanol vapor for 14 hours, followed by ethanol withdrawal for 10 hours, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. Results: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. Conclusion: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats.

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Effect of Chronic Ethanol Exposure on Female Rat Reproductive Cyclicity and Hormone Secretion

Cited by 49 publications

References 22 publications

Adolescent Binge Drinking Linked to Abnormal Spatial Working Memory Brain Activation: Differential Gender Effects

Adolescent Binge Drinking Linked to Abnormal Spatial Working Memory Brain Activation: Differential Gender Effects

Long‐term alcohol exposure prior to conception results in lower fetal body weights

Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats

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