Effect of chronic kidney disease on serum resistin level

Shen, Dan; ADITYA, None PADALA; Banerjee, P K; Bal, Ceylan; Roy, Himansu; Banerjee, Indira

doi:10.4103/1119-3077.144387

Cited by 13 publications

(10 citation statements)

References 36 publications

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“…Though most analyzed cytokines trended higher in Alport ECM, only Resistin, TIM-1/KIM-1, DPPIV/CD26, and Reg3G (regenerating islet-derived protein 3 gamma) reached statistical significance. Resistin, KIM-1 and DPPIV/CD26 have been associated with proinflammatory functions and are reported to be increased in chronic kidney diseases [47–50]. Resistin is secreted mainly by adipose tissue and increases both the expression of ICAM-1 and VCAM-1 by endothelial cells and monocyte adhesion to endothelial cells via p38MAPK-dependent pathways [48].…”

Section: Discussionmentioning

confidence: 99%

A step towards clinical application of acellular matrix: A clue from macrophage polarization

et al. 2017

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The outcome of tissue engineered organ transplants depends on the capacity of the biomaterial to promote a pro-healing response once implanted in vivo. Multiple studies, including ours, have demonstrated the possibility of using the extracellular matrix (ECM) of animal organs as platform for tissue engineering and more recently, discarded human organs have also been proposed as scaffold source. In contrast to artificial biomaterials, natural ECM has the advantage of undergoing continuous remodeling which allows adaptation to diverse conditions. It is known that natural matrices present diverse immune properties when compared to artificial biomaterials. However, how these properties compare between diseased and healthy ECM and artificial scaffolds has not yet been defined. To answer this question, we used decellularized renal ECM derived from WT mice and from mice affected by Alport Syndrome at different time-points of disease progression as a model of renal failure with extensive fibrosis. We characterized the morphology and composition of these ECMs and compared their in vitro effects on macrophage activation with that of synthetic scaffolds commonly used in the clinic (collagen type I and poly-L-(lactic) acid, PLLA). We showed that ECM derived from Alport kidneys differed in fibrous protein deposition and cytokine content when compared to ECM derived from WT kidneys. Yet, both WT and Alport renal ECM induced macrophage differentiation mainly towards a reparative (M2) phenotype, while artificial biomaterials towards an inflammatory (M1) phenotype. Anti-inflammatory properties of natural ECMs were lost when homogenized, hence three-dimensional structure of ECM seems crucial for generating an anti-inflammatory response. Together, these data support the notion that natural ECM, even if derived from diseased kidneys promote a M2 protolerogenic macrophage polarization, thus providing novel insights on the applicability of ECM obtained from discarded organs as ideal scaffold for tissue engineering.

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Section: Discussionmentioning

confidence: 99%

A step towards clinical application of acellular matrix: A clue from macrophage polarization

et al. 2017

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“…We selected CAP1, a functional receptor of resistin, as a target for validation in the kidney tissue of IgAN patients. Notably, elevated resistin levels in chronic kidney disease have been reported in different studies and are associated with decreased GFR and inflammation 58 , 59 . CAP1 is essential for mediation of inflammatory action of monocytes and thus, has been suggested as potential target for treatment of inflammatory diseases 60 .…”

Section: Discussionmentioning

confidence: 99%

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis

Krochmal

Cisek

Filip

et al. 2017

Sci Rep

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IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored. We investigated a combinatorial approach for the analysis of IgAN-relevant -omics data, aiming at identification of novel molecular signatures of the disease. Nine published urinary proteomics datasets were collected and the reported differentially expressed proteins in IgAN vs. healthy controls were integrated into known biological pathways. Proteins participating in these pathways were subjected to multi-step assessment, including investigation of IgAN transcriptomics datasets (Nephroseq database), their reported protein-protein interactions (STRING database), kidney tissue expression (Human Protein Atlas) and literature mining. Through this process, from an initial dataset of 232 proteins significantly associated with IgAN, 20 pathways were predicted, yielding 657 proteins for further analysis. Step-wise evaluation highlighted 20 proteins of possibly high relevance to IgAN and/or kidney disease. Experimental validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transforming protein 1 (SHC1) and prolylcarboxypeptidase (PRCP) was performed by immunostaining of human kidney sections. Collectively, this study presents an integrative procedure for -omics data exploitation, giving rise to biologically relevant results.

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“…Its major sources in humans are monocytes and macrophages 2–4. In uremic patients, serum RES concentrations are elevated as compared to individuals with normal renal function 5. It has not been concluded whether higher RES concentration is secondary to reduced renal clearance or reflects chronic inflammation 6–8.…”

Section: Introductionmentioning

confidence: 99%

Physical activity increases the resistin concentration in hemodialyzed patients without metabolic syndrome

Hornik¹,

Duława²,

Szewieczek³

et al. 2018

DMSO

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BackgroundResistin (RES) concentration increases in end-stage renal disease patients. However, there have been no studies defining the role of physical activity in RES concentrations in hemodialyzed (HD) patients. This study was aimed to determine metabolic and inflammatory effects, including RES, of 4-week supervised rehabilitation program in HD patients, with or without metabolic syndrome (MS).MethodsThe study was completed by 28 patients aged 56.9±13.3 years (x¯±SD) who were HD for 50.6±73.4 months, and 30 controls aged 61.5±8.3 years with normal renal function. Both the groups were divided into two subgroups with respect to MS. Individualized supervised rehabilitation program based on physiotherapy, including exercises, was provided to each subject for 4 weeks. Baseline and post-intervention complete blood count, glycated hemoglobin (HbA1c) and levels of serum RES, leptin, adiponectin, cystatin C, erythropoietin, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), interleukin-6, transforming growth factor- β1, plasminogen activator inhibitor-1 homocysteine, insulin, albumin, parathyroid hormone (PTH), and phosphorus were measured.ResultsCompared to controls, HD patients showed higher baseline leucocytes count and higher serum concentrations of RES, leptin, cystatin C, hs-CRP, TNF-α, homocysteine, phosphorus, PTH while hemoglobin, glucose, and albumin concentrations. A positive correlation between serum albumin and RES concentrations was observed in HD patients. Post-intervention RES increase was observed in HD patients without MS (post-intervention 34.22±8.89 vs baseline 30.16±11.04 ng/mL; P=0.046) while no change was observed in patients with MS and in the control group.ConclusionMS modifies a RES response to the rehabilitation program in HD patients.

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Effect of chronic kidney disease on serum resistin level

Abstract: Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.

Cited by 13 publications

References 36 publications

A step towards clinical application of acellular matrix: A clue from macrophage polarization

A step towards clinical application of acellular matrix: A clue from macrophage polarization

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis

Physical activity increases the resistin concentration in hemodialyzed patients without metabolic syndrome

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