2021
DOI: 10.1111/jch.14390
|View full text |Cite
|
Sign up to set email alerts
|

Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Abstract: We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population. We included 7895 participants aged ≥30 years from the ISSA‐CKD study, a population‐based retrospective cohort study that used annual health check‐up data of residents from Iki Island, Japan. After the exclusion of 1881 with l < 1‐year follow‐up, 2812 with hypertension at baseline, an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
7
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 7 publications
(8 citation statements)
references
References 33 publications
1
7
0
Order By: Relevance
“…In addition to the association between SUA level and failure to achieve treatment BP goals, our data showed a relationship between SUA quartiles and BP measurements in both sexes (1.07-1.70) in the fourth quartile compared with those in the reference group (p = .007 for trend). 26 Thus, it is possible that maintaining optimal SUA levels contributes to better management of BP through these previous reports and our results.…”
Section: Discussionsupporting
confidence: 71%
See 1 more Smart Citation
“…In addition to the association between SUA level and failure to achieve treatment BP goals, our data showed a relationship between SUA quartiles and BP measurements in both sexes (1.07-1.70) in the fourth quartile compared with those in the reference group (p = .007 for trend). 26 Thus, it is possible that maintaining optimal SUA levels contributes to better management of BP through these previous reports and our results.…”
Section: Discussionsupporting
confidence: 71%
“…After adjusting for baseline covariates, SUA levels were significantly associated with hypertension ( p < .01) 25 . The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA‐CKD) study, which was a population‐based retrospective cohort study to examined the association between hyperuricemia and new‐onset hypertension in the 7895 Japanese population, reported that the first quartile SUA group was set as the reference group, and the multivariable‐adjusted hazard ratios (95% CI) for new‐onset hypertension were 1.11 (0.90–1.36) in the second quartile, 1.25 (1.02–1.54) in the third quartile, and 1.35 (1.07–1.70) in the fourth quartile compared with those in the reference group ( p = .007 for trend) 26 . Thus, it is possible that maintaining optimal SUA levels contributes to better management of BP through these previous reports and our results.…”
Section: Discussionmentioning
confidence: 99%
“…The imbalance of ROS and NOS leads to endothelial dysfunction [16] and induces plasma renin activity [17]. The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) study demonstrated that elevated SUA levels are an independent risk factor for new-onset hypertension, especially in the CKD population [18]. Otherwise, in the hypertension population, elevated SUA levels were significantly associated with the prevalence and severity of SCA, especially in the thoracic aorta affected [19].…”
Section: Discussionmentioning
confidence: 99%
“…This connection remained significant after adjusting for age, gender, hypertension, obesity, diabetes, dyslipidemia, current smoking, daily alcohol use, regular exercise, and chronic kidney disease. In addition, the stratified analysis demonstrated that the effects of hyperuricemia on the onset of hypertension were more pronounced in people with CKD than those without CKD (7). A systematic review and meta-analysis was conducted by Grayson et al which stated high blood pressure went up by 13% for every 1mg/dL increase in serum uric acid level (8).…”
Section: Hypertensionmentioning
confidence: 99%