Effect of chronic lead treatment on renal function

Hirsch, G. H.

doi:10.1016/0041-008x(73)90166-x

Cited by 32 publications

(17 citation statements)

References 12 publications

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“…Similar findings were reported by previous studies. 16,18,[36][37][38] Some lead-treated rats showed renal cysts after 11 months and more of lead exposure. This alteration is an indication of renal failure and hydronephrosis where these cysts arise as a result of nephrons blockage, with subsequent dilation and parenchymal dilation of the renal tissues.…”

Section: Discussionmentioning

confidence: 99%

“…6,[16][17][18][19][20] The histochemical alterations in the renal tissues due to chronic lead exposure is limited and have not yet been well identified. With this objective, a detailed histological and histochemical studies were undertaken on the kidney of Wistar albino rats killed at one month intervals up to 12 months after lead acetate trihydrate treatment.…”

Section: -15mentioning

confidence: 99%

“…This confirms that the nucleus is the key factor in most cell disturbances, 30 and undergoes morphological and functional alterations due to lead poisoning. Several investigators have described the development of the intranuclear inclusion bodies due to chronic lead exposure, 16,18 and considered it as an adaptation to the metabolic and functional changes in the organelles of renal cells due to lead intoxication. A histochemical characterization of the intranuclear inclusion bodies showed that these bodies are lead lipoprotein complexes containing sulfyhydryl groups and are basic in nature.…”

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Histological and Histochemical Alterations in the Kidney Induced by Lead

Jarrar

2003

Ann Saudi Med

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Background: Although lead intoxication is one of the most common forms of metal intoxication, the histochemical alterations in the renal tissues due to chronic lead exposure is limited and has not yet been well identified. Subjects and Methods: A total of 60 male Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate (0.0, 0. 25, 0.5, 1.0 and 2% for 1 to 12 months) in drinking water to investigate the histological and histochemical alterations in the renal tissues due to lead. Results: Chronic exposure to subtoxic doses of lead produced distinct progressive tubular, glomerular and interstitial damages. Tubular changes occurred earlier than glomerular and interstitial ones, and included anisokaryosis, nuclear pyknosis, karyomeglay, development of intranuclear and cytoplasmic inclusions together with tubular dilation, necrosis, vacuolization, tubular hyperplasia and solid tubular adenoma. The glomerular alterations were mainly mesangial hypercellularity, segmental proliferation, focal and segmental glomerulosclerosis, glomerular hyalinization and glomerular tuft alterations. Conclusions:The findings indicate that lead produces significant histological and histochemical changes in the kidney that lead to severe complications. Ann Saudi Med 2003;23(1-2):10-15. BM Jarrar, Histological and Histochemical Alterations in the Kidney Induced by Lead. 2003; 23(1-2): 10-15Key Words: Lead, kidney, intoxication, histology, histochemistry. Lead intoxication is probably the most common form of heavy metal intoxication, 1-3 and is well documented as one of the most dangerous and insidious poisons to man. [4][5] The absorbed lead is conjugated in the liver and is passed to the kidney, where a small quantity is excreted and the rest accumulates in and interferes with the function of body organs, especially the kidney as a target site for lead toxicity.6-9 Continuous environmental and occupational lead exposure can lead to chronic nephropathy, 6,10,11 which is a characteristic manifestation of lead toxicity and characterized by tubular, interstitial and glomerular damages, including renal lesions, tumors and cancer risk. 12-15The long-term effects of lead chronic exposure have been documented by several investigations with special attention to the exposure of developing animals and young children. 6,[16][17][18][19][20] The histochemical alterations in the renal tissues due to chronic lead exposure is limited and have not yet been well identified. With this objective, a detailed histological and histochemical studies were undertaken on the kidney of Wistar albino rats killed at one month intervals up to 12 months after lead acetate trihydrate treatment. Subjects and MethodsA total of 60 male Wistar albino rats (Rattus norvegicus) of the same age weighing 110-130 g of King Saud University colony were used. Animals were randomly divided into five groups of 12 rats each. Following a period of stabilization (7 days), lead acetate trihydrate was administered in drinking water at the rate of 0.0%, 0.25%, 0.5%, 1...

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Section: Discussionmentioning

confidence: 99%

Section: -15mentioning

confidence: 99%

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confidence: 99%

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Histological and Histochemical Alterations in the Kidney Induced by Lead

Jarrar

2003

Ann Saudi Med

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“…The following reviews are some that are useful (1,16,32,96,(152)(153)(154). A few recent references will introduce some aspects of the actions of lead on the tissues: liver (155), kidney (156)(157)(158), and nervous system (126,(159)(160)(161)(162)(163)(164)(165).…”

Section: Other Tissuesmentioning

confidence: 99%

Indices of potential lead hazard.

Posner¹

1977

Environ Health Perspect

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This review is concerned with the concentrations of lead in human whole blood, erythrocytes, plasma, serum, soft tissues, bone, and urine. The extent to which redistribution of some of the bound lead occurs is outlined. The effects of lead on enzyme activities and on the accumulation of metabolic intermediates in the blood and urine are described. A brief section deals with the range ofsigns and symptoms that can occur and differences seen between symptomatic children and adults.

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“…In the rabbit, brown granular cytoplas mic pigment, giant tubule cells, and intranuclear inclusions appear in the straight, narrow tubules near the cortico-medullary junction at 8 to 12 weeks, and later in the proximal convoluted tubules in rabbits on 500 mg Pb/100 g diet (Mass et al 1964). Histologic changes in the 30-day old rat on 2 or 4% lead acetate diet include cell vacuolation and necrosis in the distal segment of the proximal convoluted tubule (Hirsch 1973). Ultrastructural changes include mitochondrial swelling with vesiculation of cristae (Mao and Molnar 1967) prior to the appearance of inclusions (Goyer 1968).…”

Section: Kidneymentioning

confidence: 99%

Effects of lead on collagen synthesis and renal function in the rat

Rodolfo-Sioson

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Effect of chronic lead treatment on renal function

Cited by 32 publications

References 12 publications

Histological and Histochemical Alterations in the Kidney Induced by Lead

Histological and Histochemical Alterations in the Kidney Induced by Lead

Indices of potential lead hazard.

Effects of lead on collagen synthesis and renal function in the rat

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