Effect of chronic somatic diseases on the course of late‐life depression

Hegeman, Johanna M; Fenema, Esther M. van; Comijs, Hannie C.; Kok, Rob M.; Mast, Roos C. van der; Waal, Margot W. M. de

doi:10.1002/gps.4523

Cited by 29 publications

(24 citation statements)

References 54 publications

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“…Our finding that female gender is an important predictor of depressive symptoms is also consistent with a number of previous studies (Beekman et al, 2001;Djernes et al;2006;Zunzunegui et al, 2007). The relevance of chronic diseases and of all aspects of physical health has also been widely reported (Beekman et al, 2001;Hegeman et al, 2017;Ylli et al, 2016). Although our analysis suggested that financial difficulties was also an important factor in relation to depression, this variable has been less often cited in previous research (Blazer, 2003;Portellano-Ortiz et al, 2017;Ylli et al, 2016).…”

Section: Factors Associated With the Prevalence Of Depressive Symptomssupporting

confidence: 91%

Course of depressive symptoms and associated factors in people aged 65+ in Europe: A two-year follow-up

Conde-Sala

Garré-Olmo

Calvó-Perxas

et al. 2019

Journal of Affective Disorders

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Background: The epidemiology of depressive disorders presents notable differences among European countries. The objectives of the study are to determine the prevalence, incidence, persistence and remission rates of depressive symptoms and to identify risk factors and differences between four European regions. Method: Prospective cohort design using data from waves 5 and 6 (2013-15) of the Survey of Health, Ageing and Retirement in Europe. Sample size included 31,491 non-institutionalized adults aged 65+. Depressive symptoms were assessed using the EURO-D. Results: The prevalence of depressive symptoms (EURO-D ≥4) was 29.8% and 31.5%in waves 5 and 6, respectively. The risk factors associated depressive symptoms were poorer self-rated health, loneliness, impairment in ADL, female gender and financial difficulties. Incidence was 6.62 (99.9% CI: 6.61-6.63)/100 person-years and the persistence and remission rates were 9.22 and 5.78, respectively. Regarding the differences between European regions, the incidence (4.93 to 7.43) and persistence (5.14 to 11.86) rates followed the same ascending order: Northern, Eastern, Continental and Southern. The remission presented higher rates in the Eastern and Southern (6.60-6.61) countries than in the Northern and Continental (4.45-5.31) ones. Limitations: The EURO-D scale is unable to distinguish between clinically relevant depressive symptoms and major depression. Conclusion: The risk factors related to the incidence of depressive symptoms differed across European regions. In countries of eastern and southern Europe the most important predictors were female gender and impairment in ADL. Poorer self-rated health and older age were more relevant in the Northern countries, and chronic diseases were a key factor in the Continental region.

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Section: Factors Associated With the Prevalence Of Depressive Symptomssupporting

confidence: 91%

Course of depressive symptoms and associated factors in people aged 65+ in Europe: A two-year follow-up

Conde-Sala

Garré-Olmo

Calvó-Perxas

et al. 2019

Journal of Affective Disorders

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“…Netherlands Study of Depression in Old Persons (NESDO) found that the presence of cardiovascular, musculoskeletal and somatic diseases was strongly associated with depressive disorder during the two-year monitoring of the patients 33 . With each additional chronic somatic disease, the chances of developing moderate and severe chronic depression increased by 92% 34 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression in elderly and relations to chronic diseases

Gajović¹,

Kocić

Radovanovic

et al. 2021

VOJNOSANIT PREGL

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Background/Aim. Depression is the most prevalent mental disorder which affects approximately 7% of the world"s older population. This study aims at examining the prevalence of depression among older adults and its relations to chronic illnesses.Methods. This study was conducted within the National Health Survey of the Serbian population in 2013. The questionnaires used as instruments in this study were created in accordance with the questionnaires of the European Health Interview Survey -Second Wave. PHQ-8 questionnaire was used here to evaluate the presence of depressive symptoms. The relations between depression symptoms (a dependent variable) and a set of independent variables were examined with univariate and multivariate logistic regression analyses. Results. The study shows that there is a 10.0% prevalence of depression within this population with statistically significant differences between the genders -12.6% of women and 6.5% in men. The multivariate analysis reveals that multimorbidity (OR=1.89), chronic pain (OR=2.35) and self-evaluations of poor health (OR=8.37) are strongly associated to depression. In terms of individual chronic illnesses, the study shows that strokes double the odds of developing depression (OR=1.82) while the deformities of lower spine increase the occurrence of depressive symptoms by 27%. Conclusion. Depression is very frequent in older persons who suffer from chronic diseases and medical conditions. It is crucial to enable adequate screening in primary healthcare institutions in order to diagnose depression in its early stages and start its treatment as soon as possible. Apstrakt Uvod/Cilj. Depresija je najčešci mentalni poremećaj koji pogađa oko 7% starije svetske populacije. Cilj ovog istraživanja je utvrđivanje prevalencije depresije u starijoj populaciji i njene povezanosti sa hroničnim oboljenjima. Metode. Istraživanje je sprovedeno u okviru nacionalne studije "Istraživanje zdravlja stanovništva Srbije" 2013. godine. Kao istrument istraživanja korisćeni su upitnici kreirani u skladu sa upitnicima 4 Evropskog istraživanja zdravlja -drugi talas. Za procenu prisustva simptoma depresije korišćen je PHQ-8 upitnik. Povezanost prisustva depresivnih simptoma (zavisna varijabla) i skupa nezavisnih varijabli ispitana je univarijantnom i multivarijantnom logističkom regresijom. Rezultati. Rezultati ukazuju na stopu prevalencije depresije od 10.0% sa statistički značajnim razlikama među polovima -12,6% kod žena i 6,5% kod muškaraca. Multivarijantna analiza pokazuje da postoje jake veze između depresije i multimorbiditeta (OR=1.89), hroničnog bola (OR=2.35) i samoprocena lošeg zdravlja (OR=8.37). Što se tiče pojedinačnih oboljenja, studija je pokazala da moždani udari dvostruko povećavaju šanse za pojavu depresije (OR=1.82), dok prisustvo deformiteta donje kičme te šanse povećava za 27%. Zaključak. Depresija je veoma česta kod starijih osoba koje pate od hroničnih bolesti i stanja. Кljučno je omogućiti adekvatan skrining u ustanovama primarne zdravstvene zaštite kako bi se depresija dij...

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“…The use of a self-report questionnaire to assess the presence of chronic somatic diseases was found accurate compared with information gathered from a general practitioner, with the exception of selfreported peripheral vascular disease (Kriegsman et al, 1996). Therefore, self-reported pain in the calves was combined with the ankle-brachial index (ABI) to more accurately assess the presence of peripheral vascular disease (PVD) (Fowkes et al, 2008;Hegeman et al, 2017). The ABI has shown to be effective in measuring PVD and is defined as the ratio of the ankle and brachial blood pressure that predicts PVD if the score is ≤0.9 (Fowkes et al, 2008).…”

Section: Measurementsmentioning

confidence: 99%

Loneliness and cardiovascular disease and the role of late‐life depression

Hegeman

Schutter

Comijs

et al. 2017

Int J Geriat Psychiatry

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These authors contributed equally as shared first authorsObjective: Loneliness and depression have a strong reciprocal influence, and both predict adverse health outcomes at old age. Therefore, this study examines whether loneliness is associated with the presence of cardiovascular diseases taking into account the role of late-life depression. Methods: Cross-sectional data of 477 older adults in the Netherlands Study of Depressed Older Persons were used. Logistic regression analysis was performed to examine the relation between loneliness and cardiovascular disease. Depression was added to the regression model to examine whether depression is an explanatory factor in the association between loneliness and cardiovascular disease. Interaction terms between loneliness and depression and between loneliness and sex were introduced in the regression model to investigate whether depressed and non-depressed participants, and men and women differed in their association between loneliness and cardiovascular disease. Results: Of the overall group, 61% were lonely, 28% had a history of cardiovascular disease and 74% were depressed. Loneliness and cardiovascular disease were not associated in the overall group after adjustment for confounders (continuous: odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.98-1.10), p = 0.25; dichotomous: OR = 1.27, 95% CI = 0.80-2.03, p = 0.32). For women, there was an association between loneliness and cardiovascular diseases (continuous: OR = 1.13, 95% CI = 1.06-1.21, p < 0.001; dichotomous: OR = 2.64, 95% CI = 1.50-4.65, p = 0.001), but this association was not present in men (OR = 0.96, 95% CI = 0.88-1.05, p = 0.38). This association remained significant after adjustment for confounders, but it lost significance after adding depression to the model. Conclusion: For women only, there was an association between loneliness and cardiovascular disease. However, this association was explained by depression, indicating that loneliness in its own right seems not related with cardiovascular disease.

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Effect of chronic somatic diseases on the course of late‐life depression

Cited by 29 publications

References 54 publications

Course of depressive symptoms and associated factors in people aged 65+ in Europe: A two-year follow-up

Course of depressive symptoms and associated factors in people aged 65+ in Europe: A two-year follow-up

Prevalence of depression in elderly and relations to chronic diseases

Loneliness and cardiovascular disease and the role of late‐life depression

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