Effect of Chrysophyllum albidum fruit pulp powder on antioxidant and proinflammatory genes in non-diabetic and type 2 diabetic rats

Oyetayo, Folake Lucy; Akomolafe, Seun F.; Jegede, Funmilayo Olusola; Elekofehinti, Olusola Olalekan; Akinjiyan, Moses Orimoloye; Odeniyi, Ifeoluwa Adebayo

doi:10.1007/s40200-021-00921-0

Cited by 7 publications

(1 citation statement)

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“…Oral administration of naringenin enhanced the protein expression of Nrf2 and thereby increased the activities of SOD, CAT, glutathione peroxidase (GPX), GST enzymes and the levels of GSH in the pancreatic tissues of STZ-treated mice [30] . Chrysophyllum albidum fruit pulp powder (CAFPP) significantly upregulated the antioxidant genes Nrf2 (approximately 2 folds) and CAT , GST , SOD , and insulin regulation-related genes in the diabetic group ( P <0.05) compared to the diabetic control with concomitant downregulation of TNF-α and DPP4 gene expressions [53] . Berberine is a promising antidiabetic isoquinoline alkaloid that is converted into the absorbed metabolite oxyberberine, both of which can exist in blood in a protein-bound form.…”

Section: Phytochemicals Ameliorate Glycometabolic Disorders By Activa...mentioning

confidence: 99%

Phytochemical activators of Nrf2: a review of therapeutic strategy in diabetes

Qin¹,

Chen²,

Wen³

et al. 2022

ABBS

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Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D), and altered mitochondrial function and abnormal lipid distribution are closely associated with IR or T2D. Excess oxidative stress-induced mitochondrial damage leads to an imbalance in redox homeostasis, which is considered the major contributor to the progression of diabetes. A key cellular defense mechanism, namely, the nuclear factor-E2 p45-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, plays an essential protective role in combating excess oxidative stress. A series of phytochemicals are reported to improve IR and restore mitochondrial function against excess oxidative stress by activating the Nrf2-ARE signaling pathway to maintain cellular reactive oxygen species (ROS) homeostasis. The present review focuses on key knowledge gaps in the Nrf2-ARE system targeted by phytochemicals and its correlation to diabetes both in the in vitro and in vivo models and recent achievements in human clinical trials to evaluate its efficiency and safety. In addition, we provide an overview of recent research progress in nutrigenomics, precision nutrition and the interactions occurring in gut microbiota associated with the Nrf2-ARE signaling pathway and diabetes chemoprevention by phytochemicals and finally propose a future research strategy for regulating redox and microbiota balance via the Nrf2-ARE pathway. The present review aims to help us comprehensively understand the critical chemopreventive role of the Nrf2-ARE pathway targeted by phytochemicals in diabetes.

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Section: Phytochemicals Ameliorate Glycometabolic Disorders By Activa...mentioning

confidence: 99%