Effect of cigarette smoking on the course of Grohnʼs disease

Breuer-Katschinski, B.; Holländer, Norbert; Goebell, H.

doi:10.1097/00042737-199603000-00007

Cited by 109 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the risk of being operated on at least once during disease course was also increased in smokers in most previous studies (42). In our study ileal disease and most markedly The coefficient is equivalent to the natural log of the odds ratio (OR).…”

Section: Discussionsupporting

confidence: 49%

Clinical presentation of Crohn's disease: association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

Lakatos¹,

Szalay²,

Tulassay³

et al. 2005

Z Gastroenterol

View full text Add to dashboard Cite

Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. Methodology: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. Results: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. <10yrs: 29.1%, P<0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of ≥10yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. Conclusions: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.

show abstract

Section: Discussionsupporting

confidence: 49%

Clinical presentation of Crohn's disease: association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

Lakatos¹,

Szalay²,

Tulassay³

et al. 2005

Z Gastroenterol

View full text Add to dashboard Cite

show abstract

“…In another study, significant differences in surgical recurrence rates between smokers and non-smokers and for both male and female were also found. Five and 10-year recurrence rates were 43% and 64%, respectively, for smokers, with corresponding figures for non-smokers of 26% and 33% [19] . In addition, it has been shown that macroscopic lesions at the neoileum are present in 70% of smokers one year after surgery, for only 35% in non-smokers and 27% in exsmokers.…”

Section: Patient and Disease Characteristicsmentioning

confidence: 77%

Postoperative Crohn’s disease recurrence: A practical approach

Nos¹,

Domènech²

2008

WJG

View full text Add to dashboard Cite

risk patients. Nitroimidazolic antibiotics, although efficient, are associated with a high rate of intolerance and might induce irreversible side effects when used for a long-term. Thiopurines are not widely used after ileocecal resection, maybe because some concerns in giving immunomodulators in asymptomatic patients still remain. In the era of biological agents and genetic testing, a well-established preventive strategy for POR is still lacking, and larger studies to identify good clinical, serological, and genetic predictors of early POR as well as more effective drugs (or drug combinations) are needed.

show abstract

“…The risk of surgery as well as the risk for further resections during disease course is also higher in smokers, in most studies [34,41,42] . These findings were reinforced by Cottone et al [43] who have shown that macroscopic lesions on the ileal site of the anastomosis were observed 1 year after surgery in 70% of smokers, versus 35% of non-smokers and 27% of ex-smokers.…”

Section: Effect Of Smoking and Its Cessation On Clinical Course And Ementioning

confidence: 99%

Smoking in inflammatory bowel diseases: Good, bad or ugly?

Lakatos¹

2007

WJG

View full text Add to dashboard Cite

Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn's disease (CD). A recent meta-analysis partially confirmed previous findings that smoking was found to be p r o t e c t i v e a g a i n s t u l c e r a t i v e c o l i t i s a n d , a f t e r onset of the disease, might improve its course, d e c r e a s i n g t h e n e e d f o r c o l e c t o m y . H o w e v e r , smoking increases the risk of developing Crohn's disease and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Smoking cessation aggravates ulcerative colitis and improves Crohn's disease. Data are however, largely conflictive as well as the potential mechanisms involved in this dual relationship are still unknown. In this review article, the authors review the role of smoking in inflammatory bowel diseases.

show abstract

Effect of cigarette smoking on the course of Grohnʼs disease

Cited by 109 publications

References 0 publications

Clinical presentation of Crohn's disease: association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

Clinical presentation of Crohn's disease: association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

Postoperative Crohn’s disease recurrence: A practical approach

Smoking in inflammatory bowel diseases: Good, bad or ugly?

Contact Info

Product

Resources

About