Effect of cigarette smoking on plasma homocysteine concentrations

Mouhamed, Dhouha Haj; Ezzaher, Asma; Neffati, Fadoua; Douki, W.; Najjar, Mohamed Fadhel

doi:10.1515/cclm.2011.062

Cited by 43 publications

(39 citation statements)

References 12 publications

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“…Cigarette smoking has been reported to be associated with increased levels of plasma homocysteine and decreased levels of serum folate and vitamin B12 [25]. However, cigarette smoking had no significant effect on mean concentrations of plasma homocysteine, serum folate, vitamin B12, PLP and blood Pb in males in the present study.…”

Section: Discussioncontrasting

confidence: 73%

Smokeless Tobacco Use: A Risk Factor for Hyperhomocysteinemia in a Pakistani Population

Iqbal

Yakub

2013

PLoS ONE

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BackgroundSmokeless tobacco (ST) use is highly prevalent in the South Asian populations. While there have been a number of reports on association of ST consumption with cancer, very few studies have been conducted to investigate its relationship with cardiovascular disease. Hyperhomocysteinemia is a well-recognized risk factor for cardiovascular disease; however, its association with ST use has never been investigated. The objective of this study was to evaluate the relationship of ST use with hyperhomocysteinemia in an urban Pakistani population.Methodology/Principal FindingsIn a cross-sectional study for assessment of risks of hyperhomocysteinemia, 872 healthy adults (355 males and 517 females of age range 18–60 years) were recruited from a low-income population in Karachi, Pakistan. A detailed questionnaire was administered which included information about smoking, non-smoking, use of ST alone (chewing as well as sniffing) and use of ST with betel nuts. Fasting serum/plasma levels of homocysteine, folate, vitamin B12 and pyridoxal phosphate (PLP; a coenzymic form of vitamin B6) were analyzed. In this population, 43.4% males and 15.5% females were found to be regular users of ST products. Laborers and vendors were the major ST consumers. Smoking was not found to be associated with plasma/serum concentrations of homocysteine, folate, vitamin B12 and PLP. However, homocysteine concentrations in the group which consumed ST alone and the group which consumed ST along with betel nut were significantly higher compared to the non-user group (17.7±7.5 µmol/L, 25.48 µmol/L vs. 11.95 µmol/L, respectively; p<0.01). Odds ratio for the association of hyperhomocysteinemia (>15 µmol/L) was 11-fold higher in the ST-consumer group compared to the non-user group, [OR (95%CI) = 11.34 (7.58–16.96); p<0.001], when the model was adjusted for age, gender, folate and vitamin B12 status.ConclusionThis study shows a positive association between ST consumption and hyperhomocysteinemia in a low-income urban Pakistani population.

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Section: Discussioncontrasting

confidence: 73%

Smokeless Tobacco Use: A Risk Factor for Hyperhomocysteinemia in a Pakistani Population

Iqbal

Yakub

2013

PLoS ONE

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“…Various lifestyle factors, such as smoking, have been associated with an increased level of tHcy [10,11] and, thus, identification of such factors could help to prevent diseases related to hyperhomocysteinemia. In our study, an impressive high proportion of smoking pregnant women was found (25.6%).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, although smokers showed a higher average folate intake, their mean RBC folate level was lower than in nonsmokers, and, among smokers, a higher proportion had RBC folate levels below the recommended reference value. Some authors [11,28] propose a number of mechanisms that may cause this deficiency, including the interaction of some components of tobacco smoke with folic acid coenzymes, which transforms them into biologically inactive compounds that lead to decreased circulating folic acid concentrations in smokers. Besides, a limitation of our study is that we did not record the daily number of cigarettes smoked and the duration of smoking, which are important elements related to Hcy concentration [11].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors [11,28] propose a number of mechanisms that may cause this deficiency, including the interaction of some components of tobacco smoke with folic acid coenzymes, which transforms them into biologically inactive compounds that lead to decreased circulating folic acid concentrations in smokers. Besides, a limitation of our study is that we did not record the daily number of cigarettes smoked and the duration of smoking, which are important elements related to Hcy concentration [11]. Finally, since a relationship between folate, Hcy concentration and second-hand exposure to cigarette smoke has been reported [28], it would have been appropriate to assess exposure by means of serum cotinine.…”

Section: Discussionmentioning

confidence: 99%

“…Individuals with the MTHFR 677 TT genotype have been shown to have higher plasma Hcy concentrations and to be at higher risk of coronary heart disease and pregnancy complications particularly in the setting of a low folate status [1,9]. Besides, cigarette smoking has been related to increased levels of Hcy, and smokers have been shown to develop hypofolatemia [10,11]. …”

Section: Introductionmentioning

confidence: 99%

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Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

et al. 2013

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Background/Aims: An important public health issue is monitoring folate inadequacy in women of childbearing potential. The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total of 204 women were enrolled in a cross-sectional study. Folate intake was assessed by a food frequency questionnaire, and RBC folate, tHcy and MTHFR C677T genotype were determined. Results: About half of the women had a decreased RBC folate level (<305 nmol/l) and all were <906 nmol/l, even though 51% of the subjects reported use of supplements. Overall 91.5% had a high Hcy concentration. Notably, younger women, and those with a low level of education, were shown to be at higher risk of inadequate RBC folate levels. Additionally, younger women were also at higher risk of carrying the TT genotype, particularly unfavorable in the setting of a low folate status. Conclusions: Our study revealed significant folate deficiency in our Mediterranean population and higher than ideal Hcy concentrations, thus emphasizing that in these groups an improvement in the folate status is needed via a food-based approach or supplement. Consequently, public health policy strategies aiming at improved supplementation are required.

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Prevalence of hyperhomocysteinemia during routine physical examination in Guangxi Province, China and related risk factors

Qin

Wang

Qin

et al. 2017

Clinical Laboratory Analysis

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Effect of cigarette smoking on plasma homocysteine concentrations

Abstract: Cigarette smoking increases homocysteine, which is strongly correlated with cotininuria and plasma thiocyanates. Moreover, smokers had tendency to develop hypofolatemia and hypovitamin B12, particularly when the duration of consumption exceeded 20 years.

Cited by 43 publications

References 12 publications

Smokeless Tobacco Use: A Risk Factor for Hyperhomocysteinemia in a Pakistani Population

Smokeless Tobacco Use: A Risk Factor for Hyperhomocysteinemia in a Pakistani Population

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

Prevalence of hyperhomocysteinemia during routine physical examination in Guangxi Province, China and related risk factors

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