Effect of Cimetidine on Surgery for Duodenal Ulcer

Wyllie, J. H.; Alexander-Williams, J; Kennedy, T. L.; Clark, C. G.; Bell, PeterR.F.; Kirk, R. M.; MacKay, C

doi:10.1016/s0140-6736(81)92472-7

Cited by 84 publications

(23 citation statements)

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“…These results coincide with those reported by other authors [ 1,7,10,11,13], Walker [7], for example, analyzed this same phenomenon for the duodenal ulcer over 15 years (1971-1985), divided into three 5-year periods, and found a progressive decrease in the inci dence of elective surgery for duodenal ulcer.…”

Section: Discussion and Commentssupporting

confidence: 90%

“…Finally, a number of authors [1,2,7,10,11,13,15] relate the decrease in elective surgery for GDPU to the acquisition of new therapeutic medicaments for treating ulcers (pirenzepine, histamine PU-receptor antagonists, carbenoxalone, sucralfate, etc.). Thus, certain authors [7] have studied the incidence of elective surgery for uncom plicated ulcer, before and after acquiring H2 antagonists, confirming that there is a significant decrease after ac quiring them.…”

Section: Discussion and Commentsmentioning

confidence: 99%

“…In recent years, certain authors have reported a de crease in the prevalence of gastroduodenal peptic ulcer (GDPU) [1][2][3][4], This has been attributed to two funda mental aspects: on the one hand, to the existence of new pharmacological agents which enable more efficient con trol of the illness [5][6][7], and on the other, to the general use of endoscopy as an essential technique for diagnos ing peptic ulcer [8,9], Furthermore, and probably in connection with these aspects, a decrease has been reported in the number of patients operated on for GDPU, especially in cases where surgery is performed electively [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Has There Been a Decrease in the Incidence of Uncomplicated Gastroduodenal Peptic Ulcer Surgery?

Campos¹,

Paricio²,

Mompeán³

et al. 1990

Dig Surg

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Over a period of 12 years, 1,039 patients were operated on at our hospital for gastroduodenal peptic ulcer. We analyzed the indications for surgery and divided the patients into two groups: subjects operated on for refractory ulcer, and patients operated on for an ulcer complication (bleeding, perforation or stenosis). To analyze the incidence of these indications for surgery, the 12 years of study (1976–1987) were divided into three 4-year periods. Our results show a statistically significant decline (p < 0.001) in the number of refractory ulcers after 1979, mainly concerning surgery for duodenal ulcer (p < 0.001). At the same time we witnessed a statistically significant increase (p < 0.001) in ulcer bleeding, again after 1979. This increase is particularly due to an increase in the incidence of duodenal ulcer bleeding (p < 0.001). Perforation did not undergo any statistically significant modifications over the three periods. Finally we witnessed a decrease in peptic stenosis, with a statistically significant decrease for gastric ulcer (p < 0.02).

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Section: Discussion and Commentssupporting

confidence: 90%

Section: Discussion and Commentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Has There Been a Decrease in the Incidence of Uncomplicated Gastroduodenal Peptic Ulcer Surgery?

Campos¹,

Paricio²,

Mompeán³

et al. 1990

Dig Surg

View full text Add to dashboard Cite

show abstract

“…For instance, in Mid-Glamorgan in 1978 only 40%/ of women had attended by 16 weeks, and 3000 had not attended by 20 weeks.…”

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confidence: 99%

“…Furthermore, some patients, thinking themselves to be earlier in pregnancy than they really are, might miss out altogether. In practice, however, [16][17][18] weeks is currently the most popular time to book anyway, and errors in estimation of gestational age from the menstrual history are mostly overestimates.9…”

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confidence: 99%