Effect of Cinnamomum zeylanicum Bark Extracts on Clinically Important Drug Resistant Pathogenic Bacteria

Abstract

Background: Cinnamomum Zeylanicum, is one of the oldest herbal medicines and a popular spice crop used in Asian countries. It has been valued for centuries for its distinct flavor and aroma, and it also possesses various medicinal properties. In Cinnamomum Zeylanicum, there are many constituents such as cimmaldehyde, eugenol, linalool and cinnamic acid. Therapeutic compounds found in plants are gaining attention as a potential source for new drug development. Objectives : The study aims to identify potential novel treatments for bacterial infections by evaluating commercially available ethanolic extracts' in vitro antimicrobial activity and observing their effects on bacterial biological activity inhibition. Material and methods: The well diffusion method was used to examine the in vitro antimicrobial activity of an ethanol extract of Cinnamomum zeylanicum bark against both gram-positive (S. aureus and S.epidermides) and gram-negative (E. coli and P. aeruginosa) standard microbes. In this study, all pathogenic bacteria that affect humans tested were inhibited to varying degrees by the concentrations investigated. Results:The results indicate that the inhibition zone for gram positive bacteria is greater than that of gram negative bacteria at all concentrations, ranging from 19.22 (29%)mm to 18.44 (28%)mm against S. aureus and S. epidermids. The inhibition zones for E. coli and P. aeruginosa are 14.67 (22%) and 14.11 (21%) respectively. Conclusion: In this study, all pathogenic bacteria that affect humans were inhibited to varying degrees by the concentrations investigated.