Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects

Hlebowicz, Joanna; Darwiche, Gassan; Björgell, Ola; Almér, Lars‐Olof

doi:10.1093/ajcn/85.6.1552

Cited by 187 publications

(139 citation statements)

References 27 publications

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“…Yet, although there is some emerging evidence of the ability of other than macronutrient components of food to alter postprandial sugar metabolism, such evidence is to date scarce and mainly produced by in vitro and animal trials. In a recent study, the inclusion of cinnamon in a rice pudding meal lowered the postprandial glucose response (Hlebowicz et al, 2007). Moreover, blueberries were reported to have potential in the attenuation of insulin resistance in an animal trial (DeFuria et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites

Järvinen

Linderborg

et al. 2010

Eur J Clin Nutr

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Background/Objectives: Repeated postprandial hyperglycemia and subsequent mild, late hypoglycemia as well as high postprandial insulin response lead to metabolic events that may eventually develop into type 2 diabetes. The aim of this study was to assess how sea buckthorn berries as well as two sea buckthorn extraction residues modulate the postprandial metabolism after a high-glucose meal. Subjects/Methods: Ten healthy normal-weight male volunteers consumed four study breakfasts, one control (A) and three sea buckthorn meals on four distinct study days. All the meals contained yoghurt and glucose (50 g). The sea buckthorn ingredients used were dried and crushed whole berries (meal B1), supercritical fluid (SF)-carbon dioxide (CO 2 )-extracted oil-free berries (meal B2) or ethanol-extracted SF-CO 2 -extraction residue (meal B3). Blood samples for glucose, insulin and tumor necrosis factor-a analyses were collected before and during the 6-h study period. Results: Meal B1 suppressed the postprandial peak insulin response when compared with meal A (Dconcentration of 30-min peak value À21.8 mU/l, P ¼ 0.039), and stabilized postprandial hyperglycemia and subsequent hypoglycemia (Dconcentration of 30-min peak value-120-min value À30.4 mU/l, P ¼ 0.036). Furthermore, meal B2 resulted in a more stable insulin response than the control meal (Dconcentration of 30-min peak value-120-min value À25.9 mU/l, P ¼ 0.037). Conclusions: Removal of the CO 2 -soluble oil component from the berries did not show a significant change in the studied postprandial effects of the berries. The EtOH soluble components, again showed advantageous properties in both insulin and glucose responses.

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Section: Discussionmentioning

confidence: 99%

Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites

Järvinen

Linderborg

et al. 2010

Eur J Clin Nutr

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“…Although this increased after treatment is toward the normal control level, but still lower with percentage changes -11.82 and -9.93% for liver and cardiac muscle respectively. Hlebowicz et al (2007) reported that cinnamon has been shown to improve insulin receptor function by activating insulin receptor PI3-kinase and inhibiting tyrosine phosphatase. Cinnamon has also been shown to stimulate the insulin receptor activity by increasing the concentrations of the phosphorylated intracellular protein IRS-1 and increasing the binding to PI3-kinase, which leads to enhanced cellular glucose uptake (Qin et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Mahfouz¹

2010

American Journal of Biochemistry and Biotechnology

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Cinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen male Wistar rats were divided into 3 groups of 6 rats each. Group 1; control animals received starch as control diet, while group 2; rats were fed a "highfructose diet" (60%). Group 3; fructose-fed rats received orally CE (0.5 mL/rat/day) from the 16th day of fructose feeding in experimental period. The animals were maintained in their respective groups for 30 days. At the end of the experimental period, serum levels of glucose, insulin, lipid profile, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), sialic acid and soluble Fas (sFas) were assayed. Hepatic and cardiac IRS-1 levels were also evaluated. Results: Fed high fructose diet to rats induced significant elevations in serum levels of glucose, insulin, triacylglycerol, HDL-c, sialic acid, sFas and MDA, while the level of serum TAC was significantly reduced as compared to controls. Also significant reduction in the levels of hepatic and cardiac IRS-1 were recorded as compared to controls. Oral administration of cinnamon extract to fructose-fed rats alleviated the effects of fructose and these rats showed a normal level of the parameters studied. The percentage changes of IRS-1 level in fructose-fed rats before and after treatment with CE were 38.51 for liver and 31.92% for cardiac muscle. This increase in IRS-1 level after treatment is still lowered than control level with the percentage change -11.82 and -9.93% for liver and cardiac muscle respectively. There was a significant positive correlation between IRS-1 and TAC level whereas there was negative correlation between IRS-1 and MDA, sialic acid and sFas. Conclusion: This study reports interest findings that cinnamon extract enhances glucose uptake by activating insulin receptor kinase activity in rats fed high fructose diet and it has additional roles as antioxidant and anti-inflammatory agents. Thus, clinical application of cinnamon could be considered as a potential therapeutic option in humans in the treatment of insulin resistance states. So inclusion of cinnamon in the daily diet could be recommended.

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“…Awater-soluble polyphenol type-A polymer isolated from cinnamon has been shown to enhance insulin activity 40 . Many authors reported that cinnamon reduced postprandial glucose levels in human by delaying gastric emptying 41 decreasing glucose absorption…”

mentioning

confidence: 99%

Some Natural Plants in Glycemic Amelioration in Streptozotocin Induced Rats

2017

International Journal of Clinical Chemistry and Laboratory Medi

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Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects

Abstract: The intake of 6 g cinnamon with rice pudding reduces postprandial blood glucose and delays gastric emptying without affecting satiety. Inclusion of cinnamon in the diet lowers the postprandial glucose response, a change that is at least partially explained by a delayed GER.

Cited by 187 publications

References 27 publications

Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites

Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Some Natural Plants in Glycemic Amelioration in Streptozotocin Induced Rats

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