Effect of circadian on the activities of ion transport ATPases and histological structure of kidneys in mice

Abstract

The impacts of unnatural every day cycles (circadian) for 60 days on the histological structure of kidneys and ATPase activities in MF1 mice were studied. The exposure times were 16 h dark, 16 h light, 24 h dark, and 24 h light, and control exposure times were 12 h dark followed by 12 h light. Our results showed an increase in the total ATPase activity of mice in all groups. Additionally, the activity of the enzyme Na + /K + -ATPase was increased after 24 h darkness, 24 h light, and 16 h light exposures compared to control. The enzyme Mg +2 -ATPase activities of the groups were higher when exposed to 16 h light, 24 h light, 24 h darkness and 16 h darkness. The activities of total ATPase, Na + /K + -ATPase and Mg +2 -ATPase in kidneys were increased in all groups after 24 h light, 24 h darkness, 16 h darkness and 16 h light exposures. Interestingly, the activity of V-type ATPase was reduced after 16 h darkness, 24 h darkness and 16 h light. Taking everything into account, changes in the day by day cycle prompt neurotic changes, enzymatic and histological changes in the kidneys of mice. More studies should be directed to explore the impacts of light and darkness that can prompt these progressions.

Trace Elements, PPARs, and Metabolic Syndrome

“…As healthcare agents or additives, trace element intake has the potential to develop "chronotherapeutic pharmacological properties". Given that the ions of trace elements may pass cytoplasmic membranes through certain ionic channels or receptors [146,[215][216][217] and the fact that the expression of multiple ionic channels and receptors exhibits diurnal regulation [217][218][219], we suggest that the absorption of these micronutrients via channels and receptors also shows a circadian pattern. Besides, all three PPAR isoforms were found to be rhythmically expressed in some mouse tissues [220].…”