Effect of Cisapride on Gastric Emptying and Heal Transit Time of Balanced Liquid Meal in Healthy Subjects

Lazzaroni, M.; Sangaletti, O.; Porro, G. Bianchi

doi:10.1159/000199476

Cited by 20 publications

(8 citation statements)

References 8 publications

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“…Our findings are also in accordance with those of others (Horowitz et al, 1987) who found no significant change in oesophageal transit after cisapride administration in patients with systemic sclerosis. The increase in the number of fundic gastric contractions after cisapride administration in our patients is consistent with the findings of most studies which demonstrated that cisapride shortens gastric emptying of liquids and solids in healthy subjects, or patients with delayed gastric emptying of idiopathic, diabetic, or postsurgical origin (Feldman & Smith, 1987;Jian et al, 1985;Lazzaroni et al, 1987;Miiller-Lissner et al, 1986), or patients with systemic sclerosis (Horowitz et al, 1987).…”

Section: Resultssupporting

confidence: 91%

The effect of cisapride on gastro‐oesophageal dysfunction in systemic sclerosis: a controlled manometric study.

Kahan¹,

Chaussade²,

Gaudric³

et al. 1991

Brit J Clinical Pharma

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1. Cisapride is a novel prokinetic drug which facilitates or restores motility throughout the gastrointestinal tract. Its mechanism of action is thought to involve enhancement of acetylcholine release in the myenteric plexus of the gut. 2. The effect of intravenous cisapride 10 mg on gastro‐oesophageal dysfunction was investigated in 20 patients with systemic sclerosis, using a double‐blind, randomised, cross‐over, placebo‐controlled manometric study design. 3. The increase in lower oesophageal sphincter pressure was significantly higher after cisapride (mean +/‐ s.e. mean, 8.3 +/‐ 2.1 cm H2O) than after placebo (mean +/‐ s.e. mean. 0.1 +/‐ 0.3 cm H2O) (P less than 0.001). The increase in the number of fundic gastric contractions during the 30 min study period was significantly higher after cisapride (mean +/‐ s.e. mean, 7.7 +/‐ 2.3) than after placebo (mean +/‐ s.e. mean, 0.9 +/‐ 0.6) (P less than 0.01). 4. No serious clinical adverse effects were observed. 5. The study demonstrates that intravenous cisapride induces a significant increase in lower oesophageal sphincter pressure and in the number of fundic gastric contractions, which may be beneficial in the treatment of scleroderma gastro‐oesophageal dysfunction. Further long‐term studies of the effect of oral cisapride in patients with systemic sclerosis are warranted.

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Section: Resultssupporting

confidence: 91%

The effect of cisapride on gastro‐oesophageal dysfunction in systemic sclerosis: a controlled manometric study.

Kahan¹,

Chaussade²,

Gaudric³

et al. 1991

Brit J Clinical Pharma

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“…In man the prokinetic agents metoclopramide (Behar & Ramsby, 1978) and cisapride (Lazzaroni, Sangaletti & Porro, 1987) accelerate gastric emptying, even in subjects with a normal rate of emptying, suggesting that the normal rate of emptying is not the maximum rate, i.e. it is to some extent inhibited (Johnson, 1989).…”

Section: Introductionmentioning

confidence: 99%

Control of gastric emptying in the pig: influence of cholecystokinin, somatostatin and prokinetic agents

Pc¹,

McFadyen²,

Rayner³

1995

Experimental Physiology

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SUMMARYThe influence of systemic arterial infusions of cholecystokinin octapeptide (CCK8) and somatostatin, and injections of cisapride, metoclopramide and atropine on gastric emptying were studied in eight pigs. Gastric emptying of dry matter (DM) and liquids (Cr-EDTA as marker) was measured, in pigs fitted with a gastric cannula, by evacuation of gastnc contents either immediately after the pigs had finished feeding, or 3 h after being fed a meal containing 1200 g of a finely ground barley diet mixed with 2-4 1 water. Gastric emptying of DM and liquids during the feeding period was not significantly altered by cisapride (0.15 and 0-3 mg kg-'-1), metoclopramide (0-2 mg kg-'), CCK8 (250 ng kg-' h-1) or somatostatin (1.8 and 4-5 jug kg-1 h-1); atropine (0.06 mg kg-') slowed emptying of DM (by 53 + 6 %; P < 0 001) and of liquids (by 51 + 7 %, P < 0.01). In contrast, the amount of DM emptied within 3 h of feeding was significantly reduced with CCK8 (250 ng kg-1 h-1; by 14 + 3 %, P < 0.001) and with somatostatin (1 8 jug kg-1 h-1; by 10± 4%; P < 0001). There was no increase in emptying of DM or liquids with cisapride or metoclopramide; indeed, there was actually a reduction in liquid emptying (by 13 + 6%; P < 0 05) with cisapride (0 3 mg kg-'). Gastric emptying in the pig is therefore resistant both to stimulation by prokinetic agents, and to inhibition by some putative neurohormonal modulators at the doses used; gastric emptying during feeding is even more resistant to alteration than is emptying between meals. It is concluded that in the pig, neither CCK nor somatostatin are involved in regulation of gastric emptying during the feeding period, but that both may play a minor role in regulation of emptying between meals. The low sensitivity to CCK may be a factor in the rapid gastric emptying of the pig.

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“…In two studies, ultrasonography showed the effectiveness of cisapride administered intravenouslyY In five studies of gastric emptying rate after the oral administration of cisapride, the results were conflicting. Lazzaroni et al, 25 Madsen, 4 and Van Wyk et al? 5 reported accelerated gastric emptying, whereas Edwards et al?…”

Section: Discussionmentioning

confidence: 99%

Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study

et al. 1996

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An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6 +/- 4.3 to 51.0 +/- 4.4 min (P = 0.0284). We conclude that a single oral dose of 5 mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.

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Effect of Cisapride on Gastric Emptying and Heal Transit Time of Balanced Liquid Meal in Healthy Subjects

Cited by 20 publications

References 8 publications

The effect of cisapride on gastro‐oesophageal dysfunction in systemic sclerosis: a controlled manometric study.

The effect of cisapride on gastro‐oesophageal dysfunction in systemic sclerosis: a controlled manometric study.

Control of gastric emptying in the pig: influence of cholecystokinin, somatostatin and prokinetic agents

Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study

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