<b><i>Background:</i></b> The present study examined whether patient characteristics, management, and outcome of kidney transplant recipients (KTx) with COVID-19 changed in the second versus the first pandemic wave. <b><i>Methods:</i></b> We reviewed all available data (demographics, medical history, comorbidities, therapeutic interventions, and outcome) on our KTx with COVID-19 during the first wave (MarchâSeptember 2020, <i>n</i> = 33) and the second wave (October 2020âFebruary 2021, <i>n</i> = 149) of the COVID-19 pandemic. <b><i>Results:</i></b> One hundred eighty-two out of our 1,503 KTx in active follow-up got COVID-19 during 12-month period, corresponding to a prevalence of 12.1%. No difference was found in age, gender distribution, comorbidities, body mass index, or baseline immunosuppression between the 2 COVID-19 waves. Bilateral COVID pneumonia was more frequent during the first wave. More KTx were managed as outpatients during the second wave (15 vs. 39%, <i>p</i> < 0.01). Calcineurin inhibitors were more sparingly reduced during the second wave, whereas antimetabolites were similarly reduced (91 vs. 86, <i>p</i> = ns). Admission to intensive care units was comparable between the first (27%) and second waves (23%). During the first wave, 8 out of 9 patients (89%) requiring intensive care died, whereas the mortality of the ICU patients in the second wave was 68% (23 deaths) (<i>p</i> = 0.2). The overall mortality was 24% during the first wave and 16% during the second wave (<i>p</i> = 0.21), while in-hospital mortality was identical between the COÂVID-19 waves (27%). Increasing age and poor allograft function were significant predictors of mortality. <b><i>Conclusions:</i></b> Most patient characteristics and outcome were comparable between the first 2 COVID-19 waves. More KTx were managed as outpatients without an overall negative impact on outcome.