Effect of Clomiphene Citrate on Ovulation Induction and Hormones of Infertility with Inflammatory Effects on Gingiva

Abstract

Objective: To determine clomiphene citrate effect on ovulation induction and its effects and evaluation on inflammation of gingiva. Materials and Methods: This was a clinical trial on 50 patients using clomiphene citrate [CC] for ovulation induction and 50 patients with control. These women were examined for their dental hygiene, and to evaluate the index of gingiva, and index of plaque, gingival crevicular fluid, and how much bleeding occurs when probing, any inflammation and dental caries. All the results were compared with a control group in this evaluation [50 females] who do not use ovulation medicines. Results: Clomiphene citrate is used for ovulation induction. It alters the hormonal level in serum and also leads to gingival inflammation. Although same level of plaque is P > 0.05, females having CC treatment for ovulation induction for more than three to four months with increase inflammation pg gingiva level respectively having value of P < 0.01, P < 0.001 and P < 0.001, respectively), GCF volume is P <0.001) and bleeding is with P <0.001 as it was compared with control group and to treatment with CC for three months.. Conclusion: It is concluded that hormonal disturbance in infertility and drugs used in present study may cause gingival inflammation. Keyword: Clomiphene citrate, luteinizing hormone, follicle stimulating hormone, inflammation, Gingivitis.