Effect of co-existent components in CO2 supercritical fluid extract of Angelica Sinensis Radix on metabolism of Z-ligustilide after oral administration in rats

n‐butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis

“…Here, we found that BP treatment inhibited the trend of transition from “type II” to “type I” as evidenced by attenuating the dark staining of NADH in the gastrocnemius muscles of the ALS mice. Consistent with previous reports in which BP can protect cells against oxidative stress, our present study found that BP treatment reversed the high level of MDA production in the spinal cords of ALS mice, indicating an increased level of reactive oxygen species . Therefore, BP may protect cells against oxidative stress by activating the nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway, which participates in the transcription activation of many antioxidative genes, such as SOD1, quinone 1, and NADH dehydrogenase …”

“…Consistent with previous reports in which BP can protect cells against oxidative stress, our present study found that BP treatment reversed the high level of MDA production in the spinal cords of ALS mice, indicating an increased level of reactive oxygen species. 41,42 Therefore, BP may protect cells against oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, 41 which participates in the transcription activation of many antioxidative genes, such as SOD1, quinone 1, and NADH dehydrogenase. 41 More and more evidences have suggested that autophagy plays an important role in ALS pathogenesis.…”

Innovative Emerging Technologies for Extraction of Phytochemicals From Natural Sources

“…Hence, the traditional proces s of extraction which includes separating the active ingredient from the raw material by employing a suitable solvent is now changing significantly into modern techniques (Shinde and Dhalwal 2009). Due to their capacity to resolve many of the drawbacks of traditional technologies, the developing technologies including SFE, PEF, MWE, UE, and HPP are becoming more widely used (Marleny et al, 2010, Zhao et al, 2014, Devgun et al, 2009, Noelia Lopezet al, 2009, Leksawasdi et al, 2022. Innovative extraction techniques, as opposed to traditional options, provide larger yields in very little time, need fewer organic solvents, and use less energy (Danijela Bursac Kovacevic et al, 2018).…”

“…The SFE is a process that separates or extracts chemical components from a matrix by employing carbon dioxide as the solvent for extraction under conditions of critical temperature and pressure (Zhao et al, 2014). The phase separation can enable the accumulation of pure CO2 solvent (gas), allowing it to be redistributed into storage and available for reuse, lowering total energy expenditures and boosting overall sustainability.…”