Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

Kašparová, Svatava; Sumbalová, Zuzana; Bystrický, Peter; Kucharská, J; Liptaj, Tibor; Mlynárik, Vladı́mir; Gvozdjáková, A

doi:10.1016/j.neuint.2005.09.002

Cited by 56 publications

(34 citation statements)

References 56 publications

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“…Absolute quantitation of metabolites from in vivo tissues is problematic since it is not possible to use an internal reference standard, and therefore metabolite concentrations are usually expressed as a ratio to a metabolite that does not change with disease or intervention. Many neurological conditions that have been successfully characterized by MRS include epilepsy, 35 amyotrophic lateral sclerosis (ALS), 36,37 Parkinson's disease (PD), 38,39 HD, 28,39 and AD, 40,41 to name but a few. MRS has also been used to increase the specificity of noninvasive diagnosis of brain tumors.…”

Section: History Of Nmr Technology In Studying Neurological Disordersmentioning

confidence: 99%

“…Although many changes observed in neurological disorders are associated with specific neuroanatomical regions and are disease specific, certain metabolic changes are globally indicative of degeneration. The most common of these changes is a decrease in N-acetylaspartate (NAA) in brain tissues, which is indicative of neural loss and has been reported following AD, 41,48 HD, 79 -81 Rett's syndrome, 82 PD, 39,83 ALS, 36,37 multiple sclerosis, 23,84 Batten's disease, 85 and traumatic brain injury. 86 A summary of the key NMR spectroscopic-based studies in neurodegenerative disease and models of neurological disorders are listed in Table 1.…”

Section: Applications Of High-resolution Nmr Spectroscopy In Neurologmentioning

confidence: 99%

“…Bender et al, 90 Verbessem et al, 142 Matthews et al, 150 Tabrizi et al, 146 Kasparova et al 39 Evaluation of striatal allografts in primate model of HD Palfi et al 114 Evaluation of ciliary neurotrophic factor in primate model of HD Mittoux et al 115 Metabolic profiling of blood sera from HD patients Underwood et al 122 Alzheimer's disease Metabolic characterization to improve the understanding and diagnosis of AD Fernandez et al, 40 Pfefferbaum et al, 41 Cheng et al, 48 Frederick et al 127 Schizophrenia Metabolic characterization of human brain tissues from schizophrenic patients Prabakaran et al 17 Bipolar disorder Biomarker evaluation Gallelli et al 33 …”

Section: Preclinical Metabonomic Studiesmentioning

confidence: 99%

“…Our own preliminary NMR spectroscopic studies have shown a global increase in succinate and decreased concentrations of NAA, N-acetylaspartylglutamate, and taurine, together with a decrease in GABA levels specific to the ventral and dorsal portions of the striatum (manuscript in preparation). Subsequent metabonomic studies have been performed to assess possible therapeutic strategies in toxin models of HD, including drugs to correct brain energy deficits, 39 striatal allografts, 114 and neurotrophic factors. 115 Xenobiotic studies.…”

Section: Human Brain Tumors Characterize and Differentiate Types Of Bmentioning

confidence: 99%

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The application of NMR-based metabonomics in neurological disorders

2006

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Summary: Advances in postgenomic technologies have radically changed the information output from complex biological systems, generating vast amounts of high complexity data that can be interpreted by means of chemometric and bioinformatic methods to achieve disease diagnosis and prognosis. Highresolution nuclear magnetic resonance (NMR) spectroscopy of biofluids such as plasma, cerebrospinal fluid (CSF), and urine can generate robust, interpretable metabolic fingerprints that contain latent information relating to physiological or pathological status. This technology has been successfully applied to both preclinical and clinical studies of neurodegenerative diseases such as Huntington's disease, muscular dystrophy, and cerebellar ataxia. An extension of this technology, 1 H magicangle-spinning (HRMAS) NMR spectroscopy, can be used to generate metabolic information on small intact tissue samples, providing a metabolic link between metabolic profiling of biofluids and histology. In this review we provide a summary of high-resolution NMR studies in neurodegenerative disease and explore the potential of metabonomics in evaluating disease progression with respect to therapeutic intervention.

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Section: History Of Nmr Technology In Studying Neurological Disordersmentioning

confidence: 99%

Section: Applications Of High-resolution Nmr Spectroscopy In Neurologmentioning

confidence: 99%

Section: Preclinical Metabonomic Studiesmentioning

confidence: 99%

Section: Human Brain Tumors Characterize and Differentiate Types Of Bmentioning

confidence: 99%

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The application of NMR-based metabonomics in neurological disorders

2006

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“…Vitamin E treatment has been used in oxidative phosphorylation disorders [16]. Beneficial effects of coenzyme Q and [22].…”

Section: Vitamin Ementioning

confidence: 99%

Vitamins in Mitochondrial Function

Kucharská

2008

Mitochondrial Medicine

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Vitamins are essential in metabolic reactions in the body as catalysts in enzymatic reactions or as coenzymes carrying chemical groups between enzymes. Many vitamins function in enzyme complexes participating in mitochondrial respiration and energy production or they are required for synthesis of mitochondrial respiratory chain components. Biosynthesis of the component of mitochondrial respiratory chain, coenzyme Q, is dependent on vitamins B 2 , B 6 , B 12 , folic acid, pantothenic acid, niacinamide and vitamin C. Vitamins B 1 , B 2 , B 6 , niacin, biotin, folic acid and pantothenic acid are important for metabolic pathways in mitochondrial respiration and energy production. Vitamins C, E, niacin and folic acid belong to effective scavengers of free radicals, prevent mitochondrial oxidants formation and mitochondrial aging. Some mitochondrial diseases are linked to vitamin deficiencies and can be improved by vitamin supplementation.

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Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy

2013

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Mitochondrial dysfunction is at the base of development and progression of several psychiatric and neurologic diseases with different etiologies. MtDNA/nDNA mutational damage, failure of endogenous antioxidant defenses, hormonal malfunction, altered membrane permeability, metabolic dysregulation, disruption of calcium buffering capacity and ageing have been found to be the root causes of mitochondrial dysfunction in psychatric and neurodegenerative diseases. However, the overall consequences of mitochondrial dysfunction are only limited to increase in oxidative/nitrosative stress and cellular energy crises. Thus far, extensive efforts have been made to improve mitochondrial function through specific cause-dependent antioxidant therapy. However, owing to complex genetic and interlinked causes of mitochondrial dysfunction, it has not been possible to achieve any common, unique supportive antioxidant therapeutic strategy for the treatment of psychiatric and neurologic diseases. Hence, we propose an antioxidant therapeutic strategy for management of consequences of mitochondrial dysfunction in psychiatric and neurologic diseases. It is expected that this will not only reduces oxidative stress, but also promote anaerobic energy production.

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Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

Cited by 56 publications

References 56 publications

The application of NMR-based metabonomics in neurological disorders

The application of NMR-based metabonomics in neurological disorders

Vitamins in Mitochondrial Function

Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy

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