Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits

Singh, Ram B.; Shinde, Suresh N.; Chopra, Raj; Niaz, Mohammad A.; Thakur, A. K.; Onouchi, Zenshiro

doi:10.1016/s0021-9150(99)00273-7

Cited by 48 publications

(33 citation statements)

References 25 publications

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“…Coenzyme-Q 10 supplementation made a significant increase in the antioxidant markers while, the level of oxidative marker MDA showed significant decrease comparing with the HC group. These results were in accordance with previous researches [58]. The relationship between oxidative stress and cholesterol levels was confirmed in many studies [61 -63].…”

Section: Discussionsupporting

confidence: 93%

“…Singh et al reported that Co Q 10 reduce the lipid levels and increase in HDL-C levels due to inhibition of LDL-C oxidation and reduce oxidative stress [57]. Moreover, Modi et al stated that the Co Q 10 lowered serum triglycerides due to either a decrease in VLDL-C synthesis or channeling of VLDL-C to pathway other than to LDL or an increase in lipoprotein lipase activity [58]. In addition, higher total serum cholesterol and LDL-C correlate with a more rapid cognitive decline in patients with AD [59].…”

Section: Discussionmentioning

confidence: 99%

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Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

El-Haleem¹,

Yassen²,

Raafat³

2014

IOSRJDMS

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

El-Haleem¹,

Yassen²,

Raafat³

2014

IOSRJDMS

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“…CoQ 10 is used for dietary supplementation studies because it is stable and effectively converted into the antioxidant active CoQ 10 H 2 on intestinal uptake. 28 Recently, an antiatherogenic effect of CoQ 10 was reported for rabbits fed an undefined preoxidized diet, 29 and we observed that 1% wt/wt CoQ 10 significantly reduced atherosclerosis in apoEϪ/Ϫ mice. 30 CoQ 10 H 2 is an effective coantioxidant, [31][32][33] and coenrichment with VitE plus CoQ 10 H 2 (VitEϩCoQ 10 H 2 ) effectively inhibits LDL lipid peroxidation, whereas VitE supplementation alone promotes this process under the mild in vitro oxidizing conditions used.…”

mentioning

confidence: 59%

Dietary Cosupplementation With Vitamin E and Coenzyme Q ₁₀ Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice

Thomas

Leichtweis

Pettersson

et al. 2001

ATVB

127

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Abstract-Intimal oxidation of LDL is considered an important early event in atherogenesis, and certain antioxidants are antiatherogenic. Dietary coenrichment with vitamin E (VitE) plus ubiquinone-10 (CoQ 10 , which is reduced during intestinal uptake to the antioxidant ubiquinol-10, CoQ 10 H 2 ) protects, whereas enrichment with VitE alone can increase oxidizability of LDL lipid against ex vivo oxidation. In the present study, we tested whether VitE plus CoQ 10 cosupplementation is more antiatherogenic than either antioxidant alone, by use of apolipoprotein E-deficient (apoEϪ/Ϫ) mice fed a high-fat diet without (control) or with 0.2% (wt/wt) VitE, 0.5% CoQ 10 , or 0.2% VitE plus 0.5% CoQ 10 (VitEϩCoQ 10 ) for 24 weeks. None of the supplements affected plasma cholesterol concentrations, whereas in the VitE and CoQ 10 groups, plasma level of the respective supplement increased. Compared with control, plasma from CoQ 10 or VitEϩCoQ 10 but not VitE-supplemented animals was more resistant to ex vivo lipid peroxidation induced by peroxyl radicals. VitE supplementation increased VitE levels in aorta, heart, brain, and skeletal muscle, whereas CoQ 10 supplementation increased CoQ 10 only in plasma and aorta and lowered tissue VitE. All treatments significantly lowered aortic cholesterol compared with control, but only VitEϩCoQ 10 supplementation significantly decreased tissue lipid hydroperoxides when expressed per parent lipid. In contrast, none of the treatments affected aortic ratios of 7-ketocholesterol to cholesterol. Compared with controls, VitEϩCoQ 10 supplementation decreased atherosclerosis at the aortic root and arch and descending thoracic aorta to an extent that increased with increasing distance from the aortic root. CoQ 10 significantly inhibited atherosclerosis at aortic root and arch, whereas VitE decreased disease at aortic root only. Thus, in apoEϪ/Ϫ mice, VitEϩCoQ 10 supplements are more antiatherogenic than CoQ 10 or VitE supplements alone and disease inhibition is associated with a decrease in aortic lipid hydroperoxides but not 7-ketocholesterol.

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“…In addition, it might also result in a reduction in the risk of atherosclerosis, because the ratio of HDL-C was significantly higher than in the rats supplemented with only high cholesterol diet. Singh et al (2000) reported that Coenzyme Q10 decreased the aortic cholesterol, triglycerides, sudanophilia and aortic and coronary artery plaque sizes, coronary atherosclerosis index, aortic and coronary atherosclerosis scores in trans-fatty rich diet. The reduction in lipid levels and increase in HDL-C levels may be due to inhibition of LDL-C oxidation and reduce oxidative stress.…”

Section: Discussionmentioning

confidence: 96%

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Al-Attar¹

2010

American Journal of Pharmacology and Toxicology

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Problem statement: Hyperlipidemia is well known to play a main role in the development of atherosclerosis. It is characterized by abnormally elevated cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in the blood. It has been recognized for many years that hypercholesterolemia is a major risk factor for cardiovascular diseases such as atherosclerosis, myocardial infraction, heart attacks and cerebrovascular diseases. In recent years, Coenzyme Q10 has gained considerable attention as a dietary supplement capable of influencing cellular bioenergetics and as a supplementary treatment for some chronic diseases. Approach: The present study was undertaken to evaluate whether Coenzyme Q10 supplementation would alter high cholesterol dietinduced hypercholesterolemic model in female rats. Sixty female albino rats of the Wistar strain weighing between 34.3 and 42.1 g were used. The experimental animals were divided into six groups. Rats of group 1 served as controls, fed with standard diet and had free access to water for three months. Rats of group 2 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months. Animals of group 3 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 4 were daily supplemented with 1 mL of corn oil /rat for two months. The experimental rats of group 5 were daily supplemented with 1 mL of corn oil /rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 6 were supplemented with 1 mg Coenzyme Q10/rat at third month. The body weight percentage changes were determined after second and third months in all experimental groups. Results: After 2 months, the maximum changes of body weight were noted in groups treated with high cholesterol diet and corn oil. After three months, the maximum percentage changes were observed in groups two and four and the minimum changes were noted in sixth group supplemented with only Coenzyme Q10 at last period. Serum triglycerides, cholesterol, High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), Atehrogenic Index (AI) and HDL Cholesterol (HDL-C) ratio were assessed at the end of experimental period. Significant increases in the levels of triglycerides, cholesterol, LDL-C VLDL-C were noted in rats supplemented with high cholesterol diet, while the level of HDL-C was significantly reduced. Similar observations were noted in rats treated with high cholesterol diet plus Coenzyme Q10. Statistically, the treatment of Coenzyme Q10 in rats subjected to high cholesterol diet showed a decrease in the change levels of these parameters. Also, the Atehrogenic Index (AI) value was significantly elevated in rats supplemented with high cholesterol diet compared with control value. Administration of Coenzyme Q10 for a peri...

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Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits

Cited by 48 publications

References 25 publications

Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

Dietary Cosupplementation With Vitamin E and Coenzyme Q ₁₀ Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

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Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits

Cited by 48 publications

References 25 publications

Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

Protective role of coenzyme Q 10 against high cholesterol dietinduced histological and biochemical changes in cerebellar cortex of adult albino rats

Dietary Cosupplementation With Vitamin E and Coenzyme Q 10 Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

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Dietary Cosupplementation With Vitamin E and Coenzyme Q ₁₀ Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice