Effect of coenzyme Q10 on organ damage in sepsis

Abstract

OBJECTIVE: Investigating the effects of coenzyme Q10 on organ damage and survival on mice in cecal ligation perforation (CLP) model in sepsis. BACKGROUND: Coenzyme Q10 is an antioxidant molecule playing an important role in mitochondria. Mitochondrial dysfunction is an important mechanism in sepsis pathophysiology. METHODS: Nintyfour Swiss Albino male mice were divided into 8 groups. CLP was performed in Group I. Coenzyme Q10, 100 mg/kg subcutaneously, was given 5 hours after CLP to Group II and 20 hours after CLP to Group III. Sham operation was performed in Group IV, 100 mg/kg coenzyme Q10 subcutaneously was given 5 hours after sham operation to Group V and 20 hours after sham operation to Group VI. No operation was performed in Group VII; coenzyme Q10, 100 mg/kg subcutaneously, was given to Group VIII. Antibiotics and fl uid replacement were applied for 3 days. The mice still living were sacrifi ced at 576th hour. The organ damages were scored under light microscopy. RESULTS: The survival of Group I and Group II was lower than that of the control groups, but the survival in the Group III was similar to control groups. It was established that spleen, kidney, heart damage and total organ damage were decreased when compared to CLP group. CONCLUSIONS: Coenzyme Q10 is effective in decreasing histological organ damage in sepsis (Tab. 3. Fig. 1, Ref. 30).

Mitochondria‐Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long‐Term Beneficial Effect in Murine Polymicrobial Sepsis

“…Similar was true in a rat model of pneumosepsis [ 60 ] and endotoxemia [ 14 ]. Antioxidant (not mitochondria targeted) treatment did not improve survival only in three mouse studies, acute pancreatitis [ 61 ], pancreatic cancer [ 62 ], and CLP [ 63 ] models. While surprising, our protracted study design (Supplementary Figure 3) allows postulating that the reduction of survival due to SkQ1 was not a coincidental observation.…”

“…The two recent sepsis studies offer some relevant clues regarding the antioxidant treatment timing/dosage and model severity [ 13 , 63 ]. At first, CLP mice were given a single-bolus coenzyme Q10 (strong mitochondria-targeted antioxidant) at 5 h and 20 h post-CLP.…”

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

“…Reducing the antioxidant capacity (Rogobete et al, 2017) in these patients due to inefficient oxidative phosphorylation (Lorente et al, 2018) leads to an increase in free radicals (Oliveira, Pontes-de-Carvalho, Couto, & Noronha-Dutra, 2017), which is actually a possible mechanism for damage caused by the sepsis (Kumar et al, 2018). Some natural compounds and herbal derivatives have anti-inflammatory and antioxidant effects that can improve sepsis symptoms, such as zinc (Ganatra et al, 2017), magnesium (Esen et al, 2004), Q10 (Abitagaoglu et al, 2015), and curcumin (Chen, Lu, et al, 2018). Turmeric is a medicinal plant that belongs to the ginger species (Zingiberaceae), distributed throughout subtropical and tropical regions of the world, and broadly growing in Asian countries such as India and China (Yadav, Yadav, Khar, Mujeeb, & Akhtar, 2013).…”

Association of Mitochondrial Respiratory Chain Enzymes with the Risk and Mortality of Sepsis Among Chinese Children

“…CoQ10 has been proposed as an effective agent for reducing the deleterious effects of septic shock by acting as an oxygen free radical scavenger and thus stabilizing mitochondrial membranes, as well as by inhibiting the arachidonic acid metabolic pathway and the formation of various prostaglandins. There is evidence that CoQ10 is effective in alleviating histological organ damage in sepsis via mortality statistics of mice model [26]. In addition, animal studies indicated that complex I + III activity was higher in the sepsis groups than healthy controls in septic mice models caused by lipopolysaccharide, and after treatment with Simvastatin, mitochondrial complex I + III expression was increased [27].…”