Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis

Fotino, A Domnica; Thompson‐Paul, Angela M.; Bazzano, Lydia

doi:10.3945/ajcn.112.040741

Cited by 170 publications

(109 citation statements)

References 45 publications

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“…Substantial efforts have been done in numerous studies where supplementation of coenzyme Q10 has been evaluated in different conditions, like multiple sclerosis [41,42] , in Parkinson´s disease [43], in patients with renal injury treated with shockwave lithotripsy [44], in male infertility [45], and in heart disease but with inconsistent results [46][47][48]. Fotino et al reported in a meta-analysis consisting of 13 studies and 395 patients increased cardiac function after coenzyme Q10 supplementation even if the total study sample was small [49]. As endothelial function has become in the focus due to being part of the development of cardiac diseases, positive effects of supplementation of coenzyme Q10 on endothelial function has been reported in the literature [50].…”

Section: Coenzyme Q10mentioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

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Section: Coenzyme Q10mentioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

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“…It is well known because of its antioxidant role in several pathologies and it has been administered in coronary artery disease due to its cardioprotective role (Littarru et al, 2011). It is used as adjunctive therapy combined with different drugs and/or clinical interventions (Pepe et al, 2007;Fotino et al, 2012). However, CoQ 10 is still seeking solutions to overcome poor oral bioavailability problems (Beg et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Simón-Yarza

Tamayo

Benavides

et al. 2013

International Journal of Pharmaceutics

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Myocardial ischemia (MI) remains one of the leading causes of death worldwide.Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF warrants a better delivery strategy. On the other hand, the compelling evidences of the role of oxidative stress in diseases like MI encourage the use of antioxidant agents. Coenzyme Q 10 (CoQ 10 ) due to its role in the electron transport chain in the mitochondria seems to be a good candidate to manage MI but is associated with poor biopharmaceutical properties seeking better delivery approaches.The female Sprague Dawley rats were induced MI and were followed up with VEGF microparticles intramyocardially and CoQ 10 nanoparticles orally or their combination with appropriate controls. Cardiac function was assessed by measuring ejection fraction before and after three months of therapy.Results demonstrate significant improvement in the ejection fraction after three months with both treatment forms individually; however the combination therapy failed to offer any synergism. In conclusion, VEGF microparticles and CoQ 10 nanoparticles can be considered as promising strategies for managing MI.

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“…Other studies suggest that CoQ10 may improve the ejection fraction in patients with congestive heart failure [5]. The oral CoQ10 may also improve functional capacity, and endothelial function in chronic heart failure [6] without any side effects.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of coenzyme Q10 from dietary supplements by FT-NIR spectroscopy and statistical analysis

et al. 2015

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A novel, time-and money-sparing method has been developed and validated for the quantitative determination of coenzyme Q10 (CoQ10) from several dietary supplements. FT-NIR spectroscopy was applied for the examination, and a calibration model was built by partial leastsquare regression (PLS-R) using fifty dietary supplements. The combination of FT-NIRS and multivariate calibration methods is a very fast and simple way to replace the commonly used HPLC-UV method; because in contrast with the traditional techniques sample pretreatment and reagents are not required and no wastes are produced.The calibration models could be improved by different variable selection techniques (for instance interval PLS, interval selectivity ratio, genetic algorithm), which are very fast and userfriendly. The R 2 (goodness of calibration) and Q 2 (goodness of validation) of the variable selected models are highly increased, the R 2 values being over 0.90 and the Q 2 values being over 0.86 in every case. Five-fold cross-validation and external validation were applied. The developed method(s) could be used by quality assurance laboratories for routine measurement of coenzyme Q10 products.

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Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis

Abstract: Pooled analyses of available randomized controlled trials suggest that CoQ₁₀ may improve the EF in patients with CHF. Additional well-designed studies that include more diverse populations are needed.

Cited by 170 publications

References 45 publications

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Quantitative determination of coenzyme Q10 from dietary supplements by FT-NIR spectroscopy and statistical analysis

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