Effect of Coffee on Gastroesophageal Reflux Disease

Abstract

Coffee is the most popular drink in the world and coffee intake may be a risk factor for gastroesophageal reflux disease (GERD), which is a common disorder and its worldwide prevalence is increasing. However, the effect of coffee on GERD remains to be fully elucidated. The relationship between GERD and coffee consumption is not clear given the existing literature, whose results are diverse and contradictory. Existing systematic investigations are not adequate and further well-designed prospective studies are needed to clarify the effect of coffee on GERD.

Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study

“…Although the mechanism of action is not completely understood yet, it has been hypothesized that modifying roasting conditions could reduce stomachirritating compounds, namely caffeine, chlorogenic acids (CGAs), and N-alkanoyl-5hydroxytryptamides (C5HTs) [45]. Caffeine is frequently investigated as the main responsible molecule in inducing GERD symptoms [46,47]. Interestingly, a recent ongoing prospective US cohort study demonstrated a minimal change in upper gastrointestinal symptoms upon stratification by caffeine status among caffeinated beverages (coffee, soda, and tea) and a major association between decaffeinated tea and GERD symptoms [48].…”

Lifestyle Management of Gastroesophageal Reflux Disease: Evidence-Based Approaches to Improve Patient Care

“…For example, although carbonated and caffeinated beverages briefly reduce LES tone and increases TLESRs and intra-abdominal pressures, large meta-analyses do not show correlation between routine consumption and GERD symptoms at a population level. [11][12][13] In excess, these beverages may be implicated as reported by an observational study of the Nurse's Health Study II cohort, which showed increased hazard ratios for GERD symptoms when 6 or more servings of coffee, tea, or soda were consumed compared to no consumption. 14 Similar inconclusive findings have been reported in patients consuming acidic foods, tomatobased products, and specific spices.…”

The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn

“…However, physiological changes with ingestion are transient and have not been correlated with GERD symptoms as reported by a systemic review of 17 studies (20). Similarly, early literature suggests coffee decreases LES tone after ingestion (21). But despite this transient effect, the most recently published meta-analysis showed no discernable association between coffee intake, GERD symptoms, or mucosal disease.…”