Effect of colchicine on carrageenin-induced granulomatous inflammation in rats.

Tsurufuji, Susumu; Min, Kyung Rak; Mizuno, Chikako

doi:10.1248/bpb1978.2.113

Cited by 2 publications

(1 citation statement)

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“…It is likely, therefore, that constriction of vessels by the a-adrenoceptor stimulant action of noradrenaline is responsible for the inhibition of the vascular permeability. In similar fashion, colchicine injected into the carrageenin granuloma pouch also reduced both blood content and plasma exudation (Tsurufuji, Min & Mizuno, 1979 Figure 1. Blood content was determined 5 h after administration of the corticoids and plasma exudation immediately before and 5 h after administration.…”

Section: Effects Of Dexamethasone and Cortisolmentioning

confidence: 65%

Mechanism of Anti‐inflammatory Action of Glucocorticoids: Re‐evaluation of Vascular Constriction Hypothesis

Sugio

Tsurufuji

1981

British J Pharmacology

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The question whether constriction of local vessels is essential for the anti‐inflammatory action of glucocorticoids in carrageenin‐induced granulomatous inflammation was studied. The vasodilator prostaglandin E1 injected into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma tissue. Noradrenaline significantly reduced plasma exudation, possibly through α‐adrenoceptor stimulation. Cortisol and dexamethasone in doses sufficient to inhibit vascular permeability were without effect on the blood content in the granuloma tissue. The results suggest that constriction of local vessels does not play an essential role in the anti‐exudative effect of glucocorticoids in chronic proliferative inflammation.

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Section: Effects Of Dexamethasone and Cortisolmentioning

confidence: 65%