Effect of Colesevelam Hydrochloride Alone and Its Combination With Atorvastatin on Experimentally Induced Hyperlipidemia in Wistar Rats

Abstract

Atherosclerosis is a major cardio effective disorder that affects heart causing hyperlipidemia which blocks the artery, aorta and obstruct the pathway of blood flow which puts life at risk.The modern medication needs to be administered continuously and in higher doses which leads to negative drawbacks. The study aim is to give the Combination therapy treatment as per the drug mechanism of action is known and how bioavailability is also known. Five group of albino wistar rats were being experimented in this case, group I to V i.e. NC, DC, COL, ATS (40mg/kg) and ATS (10mg/kg) + COL is to give the treatment as chrono pharmacology method in combination and in low dose range of atorvastatin 10-20 mg/kg less side effect is observed. Conducting the study is seen that lower dose in combination (bile acid sequestrants and HMG-CO-A inhibitor) was proven that CK-MB levels are decreased in comparison of high dose of Atrorvastatin by Detection of Biochemical Evaluation Parameters like CK-MB, Lipid profile, CBC etc. also Detect the Histopathological parameters by differentiate the slide review of Heart and Aorta of every group according to plan of work and protocol for evaluation of formulation. As further it will come in future work can be done into cell line on molecular base to determine clinical significance.