Effect of Colicine Production on Escherichia coli in the Normal Human Intestine

Branche, William C.; Young, Viola Mae; Robinet, Harriette G.; Massey, Eugene D.

doi:10.3181/00379727-114-28624

Cited by 30 publications

(22 citation statements)

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“…Contrary to the situation with Staphylococcus aureus, resistance to antibiotics does not appear to play a major role (19). Production of certain colicines may influence the intestinal flora and may be an important factor in its composition (20). This subject is currently under investigation.…”

Section: Resultsmentioning

confidence: 99%

Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

Kennedy¹,

Plorde²,

Petersdorf³

1965

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

Kennedy¹,

Plorde²,

Petersdorf³

1965

J. Clin. Invest.

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“…There exists some data suggesting a role for colicins in bacterial competition, in the establishment of new bacterial strains in a bacterial community and as virulence determinants (Branche et al, 1963;Ikari et al, 1969;Kelstrup & Gibbons, 1969;Smith, 1974;Chao & Levin, 1981). However, these data are limited and often conflicting (Hardy, 1974;Pugsley, 1984).…”

Section: Introductionmentioning

confidence: 99%

A survey of Col plasmids in natural isolates of Escherichia coli and an investigation into the stability of Col-plasmid lineages

Riley

Gordon

1992

Journal of General Microbiology

144

120

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~ ~~ ~A survey of colicins in the ECOR reference collection of Escherichia coZi is presented. Twenty-five of the 72 ECOR strains exhibited a phenotype consistent with colicin production and E. coZi isolated from human hosts were more likely to be colicinogenic than those from animal hosts. Multiple representatives of two Col plasmids, lowmolecular-mass ColEl plasmids and high-molecular-mass, conjugative ColIa plasmids were isolated from the ECOR collection and were examined with a combination of restriction fragment and Southern analysis. These data suggested that ColEl plasmids comprise a stable (cohesive) plasmid lineage, while ColIa plasmids represent a family of distinct plasmid lineages united by the presence of the colicin Ia operon.

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“…A similar lack of complete correlation between in-vitro colicine assay methods has been reported by other workers (Hentges and Freter, 1962;Branche et al, 1963). The discrepancy in the results from the two typing methods is also to be expected because certain colicines-such as colicine I-diffuse slowly and are best detected after 48-72 hours' incubation whilst others are labile (Mennigmann, 1965;Kubota, et al, 1969) or are inactivated by concomitantly produced inactivators (Foulds ,and Shemin, 1969), and are therefore best detected after 24 hours' incubation.…”

Section: Discussionmentioning

confidence: 79%

Colicine Production as an Epidemiological Marker of Escherichia Coli

Hettiaratchy

Cooke

Shooter

1973

Journal of Medical Microbiology

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THE epidemiology of Escherichia coli is poorly understood, and although serological characterisation of strains affords an excellent method of typing E. coli, it is time-consuming and can be performed only in specialised laboratories. Another method would be of value. Colicine typing as a method of differentiating strains has been used (Linton, 1960;McGeachie, 1965 ;Mustafa and Dunbar, 1970), but not so extensively as serotyping and its usefulness has not been defined.Colicine typing is simple to perform and has been found valuable in epidemiological studies on shigellae (Abbott and Shannon, 1958 ;Gillies, 1964;Hart, 1965), particularly on strains of Shigella sonnei because they are serologically and often biochemically homogeneous (Hart).This paper records our experience of colicine typing of E. coli and of the validity of the method as an epidemiological tool. Serological and colicine typing were used in this investigation to determine whether the combination of the two methods would provide a finer subdivision of strains, to show the frequency of colicine production and sensitivity among serologically defined strains, and to show any correlation between colicine types and antigenic structure of the organisms. This is particularly interesting because several workers attempting to purify colicines have observed a close association between colicines and the 0 antigen of the organism (Goebel and Barry, 1958;Hutton and Goebel, 1961;Barry, Everhart and Graham, 1963).An epidemiological application of the typing method is also reported. MATERIALS AND METHODS Specimensof faeces were collected from patients in a female, open medical ward as soon as possible after admission and thereafter at weekly intervals for 1 yr. The patients were those usually seen in a general medical ward and particularly included diabetics.

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Effect of Colicine Production on Escherichia coli in the Normal Human Intestine

Cited by 30 publications

References 0 publications

Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

A survey of Col plasmids in natural isolates of Escherichia coli and an investigation into the stability of Col-plasmid lineages

Colicine Production as an Epidemiological Marker of Escherichia Coli

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